一只日本猕猴（食蟹猴）发生肝细胞癌伴颅内转移

Hepatocellular carcinoma with intracranial metastasis in a Japanese macaque (Macaca fuscata).

作者信息

Miyabe-Nishiwaki Takako, Hirata Akihiro, Kaneko Akihisa, Ishigami Akiyo, Miyamoto Yoko, Yamanaka Atsushi, Owaki Keishi, Sakai Hiroki, Yanai Tokuma, Suzuki Juri

机构信息

Primate Research Institute, Kyoto University, Aichi, Japan.

Division of Animal Experiment, Life Science Research Center, Gifu University, Gifu, Japan.

出版信息

J Med Primatol. 2017 Jun;46(3):93-100. doi: 10.1111/jmp.12261. Epub 2017 Apr 3.

DOI:10.1111/jmp.12261

PMID:28369930

Abstract

BACKGROUND

A 23-year-old male Japanese macaque (Macaca fuscata) showed left ptosis, which progressed to exophthalmos.

METHODS

The macaque underwent a clinical examination, CT and MRI, and was euthanized. Necropsy and histopathological examination were performed after euthanasia.

RESULTS

The CT revealed and MRI confirmed an intracranial mass at the skull base with orbital extension. At necropsy, there were a large hepatic mass and an intracranial mass compressing the left temporal lobe of the brain. Histopathological and immunohistological examinations revealed that the masses were hepatocellular carcinoma (HCC) and a metastatic lesion. In both the primary and metastatic lesions, neoplastic hepatocytes were arranged mainly in a trabecular pattern. Immunohistochemically, the tumor cells were positive for cytokeratin (AE1/AE3 and CAM5.2) and hepatocyte paraffin 1 and negative for cytokeratin 7 and 20 and vimentin.

CONCLUSION

To our knowledge, this is the first case report of HCC with intracranial metastasis in a macaque.

摘要

背景

一只23岁的雄性日本猕猴（猕猴属）出现左眼睑下垂，并发展为眼球突出。

方法

对这只猕猴进行了临床检查、CT和MRI检查，然后实施安乐死。安乐死后进行了尸检和组织病理学检查。

结果

CT显示并经MRI证实颅底有一颅内肿块并向眼眶扩展。尸检时，发现一个大的肝脏肿块和一个压迫左侧颞叶的颅内肿块。组织病理学和免疫组织学检查显示，这些肿块为肝细胞癌（HCC）和一个转移灶。在原发性和转移性病变中，肿瘤性肝细胞主要呈小梁状排列。免疫组织化学检查显示，肿瘤细胞细胞角蛋白（AE1/AE3和CAM5.2）及肝细胞石蜡1呈阳性，细胞角蛋白7和20及波形蛋白呈阴性。