Department of Neurology and Neuroscience Center, First Hospital of Jilin University, Changchun, People's Republic of China.
Department of Neurology, First Affiliated Hospital of Harbin Medical University, Harbin, People's Republic of China.
J Neurosci Res. 2017 Oct;95(10):2086-2090. doi: 10.1002/jnr.24044. Epub 2017 Mar 30.
Since its initial identification, Astrocyte Elevated Gene-1 (AEG-1) has been recognized as a "star" gene detected in most of the analyzed cancers; AEG-1 can interact with signaling transduction molecules, such as PI3K/Akt and MAPK, to affect the function and viability of cells. Furthermore, its multiple other functions are also gradually being recognized. AEG-1 participates in several biological processes, including embryonic development, glutamate excitotoxicity, inflammation, and endoplasmic reticulum stress. Most of the noncancerous roles of the AEG-1 were identified in studies of the neurological disorders of the CNS. As an oncogene that promotes aberrant cellular processes within the CNS, AEG-1 may also represent an important therapeutic target for the treatment of neurological disease. However, the exact role of the AEG-1 in CNS under normal conditions is still unknown. This review will focus on the literature describing the role of this molecule in CNS neurons and astrocytes during noncancerous processes. © 2017 Wiley Periodicals, Inc.
星形胶质细胞上调基因-1（AEG-1）自最初被鉴定以来，已被认为是在大多数分析的癌症中检测到的“明星”基因；AEG-1 可以与信号转导分子（如 PI3K/Akt 和 MAPK）相互作用，影响细胞的功能和活力。此外，其许多其他功能也逐渐被认识到。AEG-1 参与了几种生物学过程，包括胚胎发育、谷氨酸兴奋性毒性、炎症和内质网应激。AEG-1 的大多数非癌症作用是在 CNS 神经系统疾病的研究中确定的。作为一种在 CNS 中促进异常细胞过程的癌基因，AEG-1 也可能是治疗神经疾病的重要治疗靶点。然而，AEG-1 在正常情况下在 CNS 中的确切作用仍不清楚。这篇综述将重点介绍描述该分子在 CNS 神经元和星形胶质细胞中非癌性过程中的作用的文献。© 2017 年 Wiley 期刊出版公司
