Mori O, Hachisuka H, Sakamoto F, Nomura H, Sasai Y
Department of Dermatology, Kurume University School of Medicine, Japan.
Acta Histochem. 1988;83(1):33-8. doi: 10.1016/S0065-1281(88)80068-0.
An immunohistochemical technique for the detection of S-100 protein, neuron specific enolase (NSE), carcinoembryonic antigen (CEA) and muramidase (lysozyme) was applied to a case of the granular cell tumour. S-100 protein was detected both in the nuclei and cytoplasma of the granular cells, and NSE was weakly positive in their cytoplasms. CEA and lysozyme were negative in the tumour cells. Our results supports the concept that granular cell tumours are derived from Schwann cells.
