NPM1 mutation but not RUNX1 mutation or multilineage dysplasia defines a prognostic subgroup within de novo acute myeloid leukemia lacking recurrent cytogenetic abnormalities in the revised 2016 WHO classification.
作者信息
Weinberg Olga K, Gibson Christopher J, Blonquist Traci M, Neuberg Donna, Pozdnyakova Olga, Kuo Frank, Ebert Benjamin L, Hasserjian Robert P
机构信息
Department of Pathology, Boston Children's Hospital, 300 Longwood Ave Bader 126.2, Boston, MA, 02115.
Division of Hematology, Brigham and Women's Hospital, Dana Farber Cancer Institute, Boston, Massachusetts.
出版信息
Am J Hematol. 2017 Jul;92(7):E123-E124. doi: 10.1002/ajh.24739. Epub 2017 May 26.
Abstract
摘要
相似文献
1
NPM1 mutation but not RUNX1 mutation or multilineage dysplasia defines a prognostic subgroup within de novo acute myeloid leukemia lacking recurrent cytogenetic abnormalities in the revised 2016 WHO classification.在2016年世界卫生组织修订分类中，NPM1突变而非RUNX1突变或多系发育异常定义了一组在无复发性细胞遗传学异常的初发急性髓系白血病中的预后亚组。
Am J Hematol. 2017 Jul;92(7):E123-E124. doi: 10.1002/ajh.24739. Epub 2017 May 26.
2
Reclassification of Acute Myeloid Leukemia According to the 2016 WHO Classification.根据 2016 年 WHO 分类对急性髓系白血病进行重新分类。
Ann Lab Med. 2019 May;39(3):311-316. doi: 10.3343/alm.2019.39.3.311.
3
Multilineage dysplasia is associated with a poorer prognosis in patients with de novo acute myeloid leukemia with intermediate-risk cytogenetics and wild-type NPM1.多系发育异常与初发急性髓系白血病且具有中危细胞遗传学特征及野生型NPM1的患者预后较差相关。
Ann Hematol. 2014 Oct;93(10):1695-703. doi: 10.1007/s00277-014-2100-6. Epub 2014 May 14.
4
In rare acute myeloid leukemia patients harboring both RUNX1 and NPM1 mutations, RUNX1 mutations are unusual in structure and present in the germline.在同时携带RUNX1和NPM1突变的罕见急性髓系白血病患者中，RUNX1突变结构异常且存在于种系中。
Haematologica. 2013 Aug;98(8):e92-4. doi: 10.3324/haematol.2013.089904. Epub 2013 Jun 10.
5
Rare coincident NPM1 and RUNX1 mutations in intermediate risk acute myeloid leukemia display similar patterns to single mutated cases.中危急性髓系白血病中罕见的NPM1和RUNX1基因同时突变表现出与单基因突变病例相似的模式。
Haematologica. 2014 Feb;99(2):e20-1. doi: 10.3324/haematol.2013.099754.
6
Association of mutations with morphological dysplasia in acute myeloid leukemia without 2016 WHO Classification-defined cytogenetic abnormalities.无 2016 年世界卫生组织分类定义细胞遗传学异常的急性髓系白血病中突变与形态发育不良的关联。
Haematologica. 2018 Apr;103(4):626-633. doi: 10.3324/haematol.2017.181842. Epub 2018 Jan 11.
7
Reply to "rare coincident NPM1 and RUNX1 mutations in intermediate risk acute myeloid leukemia display similar patterns to single mutated cases". Haematologica 2014;99(2):e20-21.对《中危急性髓系白血病中罕见的NPM1和RUNX1基因同时突变与单基因突变病例表现出相似模式》的回复。《血液学杂志》2014年；99(2):e20 - 21。
Haematologica. 2014 Feb;99(2):e22. doi: 10.3324/haematol.2013.100669.
8
Helicase-like transcription factor is a RUNX1 target whose downregulation promotes genomic instability and correlates with complex cytogenetic features in acute myeloid leukemia.解旋酶样转录因子是RUNX1的一个靶点，其下调会促进基因组不稳定，并与急性髓系白血病复杂的细胞遗传学特征相关。
Haematologica. 2016 Apr;101(4):448-57. doi: 10.3324/haematol.2015.137125. Epub 2016 Jan 22.
9
Comprehensive analysis of cooperative gene mutations between class I and class II in de novo acute myeloid leukemia.初发急性髓系白血病中I类与II类基因间合作性基因突变的综合分析
Eur J Haematol. 2009 Aug;83(2):90-8. doi: 10.1111/j.1600-0609.2009.01261.x. Epub 2009 Mar 21.
10
[THE CLINICAL SIGNIFICANCE OF GENETIC MUTATIONS IN ACUTE MYELOID LEUKEMIA].[急性髓系白血病基因突变的临床意义]
Lik Sprava. 2014 Dec(12):10-8.
引用本文的文献
1
Interaction between myelodysplasia-related gene mutations and ontogeny in acute myeloid leukemia.骨髓增生异常相关基因突变与急性髓系白血病发生的关系。
Blood Adv. 2023 Sep 12;7(17):5000-5013. doi: 10.1182/bloodadvances.2023009675.
2
Clinical Outcomes of Acute Myeloid Leukemia Patients Harboring the RUNX1 Mutation: Is It Still an Unfavorable Prognosis? A Cohort Study and Meta-Analysis.携带RUNX1突变的急性髓系白血病患者的临床结局：它仍然是不良预后因素吗？一项队列研究和荟萃分析。
Cancers (Basel). 2022 Oct 26;14(21):5239. doi: 10.3390/cancers14215239.
3
Peptide microarray of pediatric acute myeloid leukemia is related to relapse and reveals involvement of DNA damage response and repair.小儿急性髓系白血病的肽微阵列与复发相关，并揭示了DNA损伤反应和修复的参与情况。
Oncotarget. 2019 Jul 23;10(45):4679-4690. doi: 10.18632/oncotarget.27086.
4
High -mutant allele burden at diagnosis predicts unfavorable outcomes in de novo AML.初诊时高突变等位基因负担可预测 AML 的不良结局。
Blood. 2018 Jun 21;131(25):2816-2825. doi: 10.1182/blood-2018-01-828467. Epub 2018 May 3.
5
Association of mutations with morphological dysplasia in acute myeloid leukemia without 2016 WHO Classification-defined cytogenetic abnormalities.无 2016 年世界卫生组织分类定义细胞遗传学异常的急性髓系白血病中突变与形态发育不良的关联。
Haematologica. 2018 Apr;103(4):626-633. doi: 10.3324/haematol.2017.181842. Epub 2018 Jan 11.
本文引用的文献
1
Clonal Hematopoiesis Associated With Adverse Outcomes After Autologous Stem-Cell Transplantation for Lymphoma.淋巴瘤自体干细胞移植后与不良预后相关的克隆性造血
J Clin Oncol. 2017 May 10;35(14):1598-1605. doi: 10.1200/JCO.2016.71.6712. Epub 2017 Jan 9.
2
The new provisional WHO entity 'RUNX1 mutated AML' shows specific genetics but no prognostic influence of dysplasia.世界卫生组织新的临时实体“RUNX1突变型急性髓系白血病”显示出特定的遗传学特征，但发育异常并无预后影响。
Leukemia. 2016 Oct;30(10):2109-2112. doi: 10.1038/leu.2016.150. Epub 2016 May 23.
3
The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia.2016 年版世界卫生组织髓系肿瘤和急性白血病分类。
Blood. 2016 May 19;127(20):2391-405. doi: 10.1182/blood-2016-03-643544. Epub 2016 Apr 11.
4
Reproducibility and prognostic significance of morphologic dysplasia in de novo acute myeloid leukemia.初发急性髓系白血病形态学发育异常的可重复性及预后意义。
Mod Pathol. 2015 Jul;28(7):965-76. doi: 10.1038/modpathol.2015.55. Epub 2015 May 15.
5
The prognostic value of multilineage dysplasia in de novo acute myeloid leukemia patients with intermediate-risk cytogenetics is dependent on NPM1 mutational status.多系发育异常在具有中危细胞遗传学特征的初发急性髓系白血病患者中的预后价值取决于NPM1突变状态。
Blood. 2010 Dec 23;116(26):6147-8. doi: 10.1182/blood-2010-09-307314.
6
RUNX1 mutations are frequent in de novo AML with noncomplex karyotype and confer an unfavorable prognosis.RUNX1 突变在非复杂性核型的初发性 AML 中频繁发生，并预示不良预后。
Blood. 2011 Feb 24;117(8):2348-57. doi: 10.1182/blood-2009-11-255976. Epub 2010 Dec 9.
Zotero 插件