Martakis Kyriakos, Hünseler Christoph, Herkenrath Peter, Thangavelu Kruthika, Kribs Angela, Roth Bernhard
Department of International Health, School CAPHRI, Care and Public Health Research Institute, Maastricht University, Maastricht, The Netherlands.
Children's and Adolescents' Hospital, University Hospital of Cologne, Cologne, Germany.
Acta Paediatr. 2017 Jul;106(7):1079-1084. doi: 10.1111/apa.13854. Epub 2017 May 3.
Our aim was to study the development of the cutaneous flexion withdrawal reflex among premature infants admitted to the neonatal intensive care unit of the Children's Hospital, University of Cologne, in 2013.
This longitudinal cohort study explored the development of spinal cord excitability of 19 premature infants born at 22-26 weeks of gestation. We performed five investigations per subject and studied changes in the reflex threshold with increasing postnatal age at different behavioural states. The premature infants were stimulated with von Frey filaments on the plantar surface of the foot near the first metatarsophalangeal joint during the first 3 days of life and at postnatal ages of 10-14 days, 21-28 days, 49-59 days and a corrected gestational age of 37-40 weeks.
The mean gestational age of the premature infants included in the study was 24 weeks. Premature infants with a gestational age of less than 26 weeks presented a flexion withdrawal reflex with a low threshold (0.5-2.85 milli-Newton) in the first 72 hours of life.
The flexion withdrawal reflex among premature infants born at less than 26 weeks showed a continuous threshold increase with increasing postnatal age, reflecting changes in spinal cord excitability.
我们的目的是研究2013年入住科隆大学儿童医院新生儿重症监护病房的早产儿皮肤屈曲退缩反射的发育情况。
这项纵向队列研究探讨了19名妊娠22 - 26周出生的早产儿脊髓兴奋性的发育情况。我们对每个受试者进行了五次调查，并研究了在不同行为状态下随着出生后年龄增加反射阈值的变化。在出生后的前3天以及出生后10 - 14天、21 - 28天、49 - 59天和矫正胎龄37 - 40周时，用von Frey细丝刺激早产儿第一跖趾关节附近足底表面。
纳入研究的早产儿平均胎龄为24周。胎龄小于26周的早产儿在出生后的前72小时表现出低阈值（0.5 - 2.85毫牛顿）的屈曲退缩反射。
胎龄小于26周的早产儿的屈曲退缩反射随着出生后年龄的增加阈值持续升高，反映了脊髓兴奋性的变化。
