Johnson I T, Gee J M, Brown J C
AFRC Institute of Food Research, Norwich Laboratory, UK.
Am J Clin Nutr. 1988 Jun;47(6):1004-9. doi: 10.1093/ajcn/47.6.1004.
The influence of dietary fiber on plasma glucagon and enteroglucagon (EG) and on ileal crypt cell production rate (CCPR) was assessed in the rat. A fiber-free semisynthetic diet and diets containing insoluble cellulose, Na-carboxymethylcellulose (CMC), guar gum, pectin, gum arabic, methylcellulose (MC), and hydroxypropylmethylcellulose (HPMC) at 10 g/100 g were fed for 14 d. Animals given soluble polysaccharides had plasma EG levels significantly higher than animals given insoluble cellulose, but only those fed the most viscous gums showed evidence of increased mucosal cell proliferation in the distal ileum. It was concluded that viscous nonfermentable polysaccharide gums stimulate the release of EG in the rat by slowing the absorption of nutrient, whereas the nonviscous polysaccharide gum arabic, or its breakdown products, probably directly stimulate mucosal endocrine cells. The failure of gum arabic to stimulate CCPR despite increased plasma EG indicated that EG alone is not a sufficient stimulus for increased mucosal cell proliferation.
在大鼠中评估了膳食纤维对血浆胰高血糖素和肠胰高血糖素（EG）以及回肠隐窝细胞生成率（CCPR）的影响。给大鼠喂食无纤维半合成饮食以及含有10 g/100 g不溶性纤维素、羧甲基纤维素钠（CMC）、瓜尔胶、果胶、阿拉伯胶、甲基纤维素（MC）和羟丙基甲基纤维素（HPMC）的饮食，持续14天。给予可溶性多糖的动物血浆EG水平显著高于给予不溶性纤维素的动物，但只有那些喂食最具粘性胶类的动物显示出回肠远端黏膜细胞增殖增加的迹象。得出的结论是，粘性不可发酵多糖胶类通过减缓营养物质的吸收来刺激大鼠体内EG的释放，而无粘性多糖阿拉伯胶或其分解产物可能直接刺激黏膜内分泌细胞。尽管血浆EG增加，但阿拉伯胶未能刺激CCPR，这表明仅EG不足以刺激黏膜细胞增殖增加。
