Graduate School of Science, Nagoya University, Chikusa, Nagoya, 464-8602, Japan.
Institute of Transformative Bio-Molecules (WPI-ITbM) and, JST-ERATO, Itami Molecular Nanocarbon Project, Chikusa, Nagoya, 464-8602, Japan.
Angew Chem Int Ed Engl. 2017 Sep 4;56(37):11144-11164. doi: 10.1002/anie.201701058. Epub 2017 Aug 10.
The annulative π-extension (APEX) reaction has the potential to have a tremendous impact on the fields of materials science and bioimaging, as well as on the pharmaceutical/agrochemical industries, since it allows access to fused aromatic systems from relatively simple aromatic compounds in a single step. Typically, an APEX reaction facilitates a one-pot π-extension without the need to prefunctionalize the aromatic compounds. This advantageous feature is extremely useful for tuning and modifying molecular properties in the last step of a synthesis. In this Review, the progress and applications of APEX reactions of unfunctionalized arenes and heteroarenes are described.
环加成 π-扩展（APEX）反应有可能对材料科学和生物成像领域以及制药/农用化学品行业产生巨大影响，因为它可以使相对简单的芳香化合物一步转化为稠合芳香体系。通常，APEX 反应促进一锅法 π-扩展，而无需对芳香化合物进行预官能化。这一有利特征在合成的最后一步中对于调整和修饰分子性质非常有用。在这篇综述中，描述了未官能化芳烃和杂芳烃的 APEX 反应的进展和应用。
