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一锅多组分 1,3-偶极环加成策略：二氢噻吩酮接枝双螺杂环稠合杂环的组合合成。

A One-Pot Multicomponent 1,3-Dipolar Cycloaddition Strategy: Combinatorial Synthesis of Dihydrothiophenone-Engrafted Dispiro Hybrid Heterocycles.

机构信息

Department of Organic Chemistry, School of Chemistry, Madurai Kamaraj University , Madurai-625021, Tamil Nadu, India.

Department of Chemistry, College of Science, King Saud University , P.O. Box 2455, Riyadh 11451, Saudi Arabia.

出版信息

ACS Comb Sci. 2017 May 8;19(5):308-314. doi: 10.1021/acscombsci.6b00186. Epub 2017 Apr 11.

DOI:10.1021/acscombsci.6b00186
PMID:28371579
Abstract

The combinatorial syntheses of a library of novel dihydrothiophenone-engrafted dispiro oxindole/indenoquinoxaline-pyrrolidine/pyrrolothiazole/indolizine hybrid heterocycles have been realized through a chemo-, regio-, and stereoselective multicomponent 1,3-dipolar cycloaddition strategy.

摘要

通过化学选择性、区域选择性和立体选择性的多组分 1,3-偶极环加成策略，实现了一系列新型二氢噻吩酮取代的双螺吲哚酮/茚并喹喔啉-吡咯烷/吡咯噻唑/吲哚嗪杂环化合物库的组合合成。

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