用于生物医学应用的明胶替代生物玻璃基骨移植材料的合成与表征
Synthesis and characterization of Bioglass-based bone grafts with Gelatine substitution for biomedical applications.
作者信息
Aksakal B, Demirel M
机构信息
Dept Metallurgy and Mater Eng, Faculty of Chemical and Metallurgy, Yildiz Technical University, Istanbul, Turkey. E-mail:
Dept of Mech Eng, Engineering Faculty, Munzur University, Tunceli, Turkey. E-mail:
出版信息
Biomed Mater Eng. 2017;28(2):159-168. doi: 10.3233/BME-171664.
BACKGROUND
Syntesizing alternative bone graft materials are important in biomedical applications. Their morphology, mechanical properties and cell viability plays an important role in tissue engineering.
OBJECTIVE
Bioglass (B) based bone grafts with Gelatin (G) substitution were syntesized via the sol-gel method and were compared with various Gelatin and Bioglass concentrations (wt%).
METHODS
Syntesized bone grafts were characterized by Scanning Electron Microscopy (SEM) and X-ray diffraction (XRD) to show the structural and morphological changes of the fabricated B-based bone grafts.
RESULTS
It was demonstrated that the concentration of pore size increased with increasing amounts of Gelatin in wt%. The biograft-B40G20 produced the highest flexture strength and hardness. Increasing the pore size caused a decrease in hardness and flexture stress of B-based biografts.
CONCLUSIONS
Cell viability tests were conducted on the fabricated biografts and it was shown that the cell viability increased in fabricated B-based bone grafts.
背景
合成替代骨移植材料在生物医学应用中很重要。它们的形态、力学性能和细胞活力在组织工程中起着重要作用。
目的
通过溶胶-凝胶法合成了含明胶（G）替代物的生物玻璃（B）基骨移植材料，并与不同浓度（重量百分比）的明胶和生物玻璃进行了比较。
方法
通过扫描电子显微镜（SEM）和X射线衍射（XRD）对合成的骨移植材料进行表征，以显示制备的B基骨移植材料的结构和形态变化。
结果
结果表明，重量百分比中明胶含量增加时，孔径浓度也增加。生物移植体-B40G20产生了最高的挠曲强度和硬度。孔径增加导致B基生物移植体的硬度和挠曲应力降低。
结论
对制备的生物移植体进行了细胞活力测试，结果表明制备的B基骨移植体中细胞活力增加。
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