Spingarn C, Wagner D, Rémond Y, George D
Laboratoire des Sciences de l'Ingenieur, de l'Informatique et de l'Imagerie (Icube), Université de Strasbourg, CNRS, 67000 Strasbourg, France.
Faculté de Chirurgie Dentaire, Hôpitaux Universitaires de Strasbourg, 67000 Strasbourg, France.
Biomed Mater Eng. 2017;28(s1):S153-S158. doi: 10.3233/BME-171636.
In this work, we present an evolutive trabecular model for bone remodeling based on a boundary detection algorithm accounting for both biology and applied mechanical forces, known to be an important factor in bone evolution. A finite element (FE) numerical model using the Abaqus/Standard® software was used with a UMAT subroutine to solve the governing coupled mechanical-biological non-linear differential equations of the bone evolution model. The simulations present cell activation on a simplified trabeculae configuration organization with trabecular thickness of 200µm. For this activation process, the results confirm that the trabeculae are mainly oriented in the active direction of the principal mechanical stresses and according to the principal applied mechanical load directions. The trabeculae surface activation is clearly identified and can provide understanding of the different bone cell activations in more complex geometries and load conditions.
在这项工作中，我们基于一种兼顾生物学和外加机械力的边界检测算法，提出了一种用于骨重塑的演化小梁模型，已知外加机械力是骨骼演化的一个重要因素。使用Abaqus/Standard®软件的有限元（FE）数值模型，并结合一个用户材料子程序（UMAT）来求解骨演化模型中耦合的机械 - 生物学非线性微分控制方程。模拟展示了在小梁厚度为200µm的简化小梁构型组织上的细胞激活情况。对于这个激活过程，结果证实小梁主要沿主机械应力的作用方向以及外加主机械载荷方向排列。小梁表面激活情况清晰可辨，这有助于理解在更复杂几何形状和载荷条件下不同的骨细胞激活情况。
