McMeekin J D, Wahl R L, Legrand V, Juni J E, Wu-Connolly L, Wathen B D
Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor 48109.
Am J Physiol Imaging. 1986;1(2):59-66.
During exercise radionuclide ventriculography (RVG), many patients cannot maintain peak workload for acquisition of more than a left anterior oblique view. To acquire further views, the workload may have to be reduced. In this study of 16 normals and 20 patients with coronary disease, the workload at peak exercise was reduced by approximately 40%. By paired t-test analysis, there was a rise in the left ventricular ejection fraction (LVEF) in patients with coronary disease from the peak exercise workload to the reduced workload level (postpeak) (52.4 +/- 15.3 to 59.3 +/- 13.7, P = .0001). There was also improvement in LVEF in the normals at the postpeak workload (71.3 +/- 11.7 to 75.1 +/- 13.7, P = .05). Of five coronary disease patients with exercise-induced wall motion abnormalities, four returned to baseline motion at the reduced exercise levels. Partial workload reduction can lead to an increase in LVEF and improvement in wall motion and thus, may result in false-negative studies.
在运动放射性核素心室造影（RVG）过程中，许多患者无法维持峰值负荷以获取超过左前斜位的图像。为了获取更多图像，可能不得不降低负荷。在这项对16名正常人和20名冠心病患者的研究中，峰值运动时的负荷降低了约40%。通过配对t检验分析，冠心病患者的左心室射血分数（LVEF）从峰值运动负荷时到负荷降低水平（峰值后）有所升高（从52.4±15.3升至59.3±13.7，P = .0001）。正常人群在峰值后负荷时LVEF也有改善（从71.3±11.7升至75.1±13.7，P = .05）。在5名有运动诱发壁运动异常的冠心病患者中，4名在运动水平降低时恢复到基线运动状态。部分负荷降低可导致LVEF升高和壁运动改善，因此可能导致假阴性研究结果。
