Labbé J C, Picard A, Dorée M
INSERM U.249 and CNRS-CRBM, Montpellier, France.
Cell Differ. 1988 Apr;23(3):201-6. doi: 10.1016/0045-6039(88)90072-3.
Progesterone stimulates the activity of a potent Ca2+- and cyclic nucleotide-independent histone kinase in Xenopus oocytes. Microinjection of ATP-gamma-S during the course of meiotic maturation or after the oocytes had arrested at second meiotic metaphase resulted in a further increase of this histone kinase activity in progesterone-stimulated oocytes. ATP-gamma-S microinjection also increased and stabilized the activity of the maturation-promoting factor. The possible mechanism of ATP-gamma-S action is discussed.
孕酮可刺激非洲爪蟾卵母细胞中一种强大的、不依赖钙离子和环核苷酸的组蛋白激酶的活性。在减数分裂成熟过程中或卵母细胞停滞于第二次减数分裂中期后显微注射γ-硫代三磷酸腺苷(ATP-γ-S),会使孕酮刺激的卵母细胞中这种组蛋白激酶的活性进一步增加。显微注射ATP-γ-S还增强并稳定了促成熟因子的活性。文中讨论了ATP-γ-S作用的可能机制。