Lewis Philip, Erren Thomas C
Institute and Policlinic for Occupational Medicine, Environmental Medicine and Prevention Research, University Hospital of Cologne , Cologne , Germany.
Front Oncol. 2017 Mar 20;7:44. doi: 10.3389/fonc.2017.00044. eCollection 2017.
Circadian disruption is associated with sleep, mood, and metabolic disorders, and-according to the International Agency for Research on Cancer-even with cancer. Mechanistically, the source of disease may be circadian system instability which likely arises during development. In animal experiments, both low perinatal light:dark ratios and chronic perinatal photoperiod phase shifting yield enduring, detrimental effects on neuroendocrine physiology circadian system instability. Certainly, accumulating disturbances to neuroendocrine physiology and detrimental downstream effects could predispose to internal cancers. Epidemiologically, either season of birth or latitude of birth, both of which co-determine perinatal photoperiod-zeitgeber strengths, have been utilized independently as proxies for other environmental co-etiologies of cancer. Both have been independently associated with cancer; however, the evidence is inconclusive. We hypothesize that time of birth and location of birth, together determining perinatal photoperiod, contribute to cancer development through erinatal ight mprinting of ircadian locks and ystems.
昼夜节律紊乱与睡眠、情绪和代谢紊乱有关，并且根据国际癌症研究机构的研究，甚至与癌症也有关。从机制上讲，疾病的根源可能是昼夜节律系统的不稳定，这种不稳定很可能在发育过程中出现。在动物实验中，围产期低明暗比和围产期慢性光周期相移都会对神经内分泌生理学产生持久的有害影响，即昼夜节律系统不稳定。当然，神经内分泌生理学累积的紊乱和有害的下游效应可能会引发体内癌症。从流行病学角度来看，出生季节或出生纬度，这两者共同决定了围产期光周期——授时因子强度，已被独立用作癌症其他环境共同病因的替代指标。两者都与癌症独立相关；然而，证据并不确凿。我们假设，出生时间和出生地点共同决定围产期光周期，通过围产期对昼夜节律锁和系统的光照印记，促成癌症的发展。
