并非所有抗体都是平等的：影响抗体介导排斥反应的因素。
Not All Antibodies Are Created Equal: Factors That Influence Antibody Mediated Rejection.
机构信息
Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
出版信息
J Immunol Res. 2017;2017:7903471. doi: 10.1155/2017/7903471. Epub 2017 Mar 8.
Abstract
Consistent with Dr. Paul Terasaki's "humoral theory of rejection" numerous studies have shown that HLA antibodies can cause acute and chronic antibody mediated rejection (AMR) and decreased graft survival. New evidence also supports a role for antibodies to non-HLA antigens in AMR and allograft injury. Despite the remarkable efforts by leaders in the field who pioneered single antigen bead technology for detection of donor specific antibodies, a considerable amount of work is still needed to better define the antibody attributes that are associated with AMR pathology. This review highlights what is currently known about the clinical context of pre and posttransplant antibodies, antibody characteristics that influence AMR, and the paths after donor specific antibody production (no rejection, subclinical rejection, and clinical dysfunction with AMR).
摘要
与 Paul Terasaki 博士的“排斥的体液学说”一致，许多研究表明 HLA 抗体可导致急性和慢性抗体介导的排斥（AMR）和移植物存活率降低。新证据也支持非 HLA 抗原抗体在 AMR 和同种异体损伤中的作用。尽管该领域的领导者们做出了卓越的努力，他们开创了用于检测供体特异性抗体的单抗原珠技术，但仍需要做大量的工作来更好地确定与 AMR 病理相关的抗体特征。本综述重点介绍了目前已知的移植前和移植后抗体的临床背景、影响 AMR 的抗体特征以及供体特异性抗体产生后的途径（无排斥、亚临床排斥和 AMR 导致的临床功能障碍）。
相似文献
1
Not All Antibodies Are Created Equal: Factors That Influence Antibody Mediated Rejection.
J Immunol Res. 2017;2017:7903471. doi: 10.1155/2017/7903471. Epub 2017 Mar 8.
2
Determining donor-specific antibody C1q-binding ability improves the prediction of antibody-mediated rejection in human leucocyte antigen-incompatible kidney transplantation.
Transpl Int. 2017 Apr;30(4):347-359. doi: 10.1111/tri.12873. Epub 2016 Nov 2.
3
Characteristics of Circulating Donor Human Leukocyte Antigen-specific Immunoglobulin G Antibodies Predictive of Acute Antibody-mediated Rejection and Kidney Allograft Failure.
Transplantation. 2015 Jun;99(6):1156-64. doi: 10.1097/TP.0000000000000511.
4
Impact of alloantibody strength in crossmatch negative DSA positive kidney transplantation.
Clin Biochem. 2013 Oct;46(15):1389-93. doi: 10.1016/j.clinbiochem.2013.05.053. Epub 2013 May 29.
5
Antibody-mediated rejection: treatment alternatives and outcomes.
Transplant Rev (Orlando). 2009 Jan;23(1):34-46. doi: 10.1016/j.trre.2008.08.004.
6
Donor specific antibodies before and after kidney transplant: the University of Colorado Experience.
Clin Transpl. 2013:407-12.
7
Analysis of preformed donor-specific anti-HLA antibodies characteristics for prediction of antibody-mediated rejection in kidney transplantation.
Transpl Immunol. 2015 Mar;32(2):66-71. doi: 10.1016/j.trim.2015.01.002. Epub 2015 Feb 7.
8
Relevance of different antibody detection methods for the prediction of antibody-mediated rejection and deceased-donor kidney allograft survival.
Hum Immunol. 2009 Aug;70(8):589-94. doi: 10.1016/j.humimm.2009.04.018. Epub 2009 Apr 15.
9
Subclinical Antibody-mediated Rejection After Kidney Transplantation: Treatment Outcomes.
Transplantation. 2019 Aug;103(8):1722-1729. doi: 10.1097/TP.0000000000002566.
10
C4D deposition and positive posttransplant crossmatch are not necessarily markers of antibody-mediated rejection in renal allograft recipients.
Transplant Proc. 2007 Nov;39(9):2718-20. doi: 10.1016/j.transproceed.2007.08.064.
引用本文的文献
1
Expanding role of antibodies in kidney transplantation.
World J Transplant. 2025 Mar 18;15(1):99220. doi: 10.5500/wjt.v15.i1.99220.
2
Allogeneic chimeric antigen receptors (CARs) as an "off-the-shelf" therapy in multiple myeloma.
Immunotherapy. 2025 Feb;17(3):211-222. doi: 10.1080/1750743X.2025.2461987. Epub 2025 Feb 17.
3
Functional and phenotypic profiles of HLA-specific antibodies in relation to antibody-mediated kidney transplant rejection.
Hum Immunol. 2025 Mar;86(2):111247. doi: 10.1016/j.humimm.2025.111247. Epub 2025 Jan 30.
4
Contribution of long-lived plasma cells to antibody-mediated allograft rejection.
Clin Transplant Res. 2024 Dec 31;38(4):341-353. doi: 10.4285/ctr.24.0047. Epub 2024 Dec 18.
5
Pushing the Survival Bar Higher: Two Decades of Innovation in Lung Transplantation.
J Clin Med. 2024 Sep 18;13(18):5516. doi: 10.3390/jcm13185516.
6
Afucosylation of HLA-specific IgG1 as a potential predictor of antibody pathogenicity in kidney transplantation.
Cell Rep Med. 2022 Nov 15;3(11):100818. doi: 10.1016/j.xcrm.2022.100818.
7
Non-HLA Antibodies in Kidney Transplantation: Immunity and Genetic Insights.
Biomedicines. 2022 Jun 25;10(7):1506. doi: 10.3390/biomedicines10071506.
8
Off-the-Shelf Chimeric Antigen Receptor Immune Cells from Human Pluripotent Stem Cells.
Cancer Treat Res. 2022;183:255-274. doi: 10.1007/978-3-030-96376-7_9.
9
Approaching the sensitized lung patient: risk assessment for donor acceptance.
J Thorac Dis. 2021 Nov;13(11):6725-6736. doi: 10.21037/jtd-2021-21.
10
Increased Autoantibodies Against Ro/SS-A, CENP-B, and La/SS-B in Patients With Kidney Allograft Antibody-mediated Rejection.
Transplant Direct. 2021 Sep 20;7(10):e768. doi: 10.1097/TXD.0000000000001215. eCollection 2021 Oct.
本文引用的文献
1
Renal Transplant Patients Biopsied for Cause and Tested for C4d, DSA, and IgG Subclasses and C1q: Which Humoral Markers Improve Diagnosis and Outcomes?
J Immunol Res. 2017;2017:1652931. doi: 10.1155/2017/1652931. Epub 2017 Jan 15.
2
Gene Expression Profiling for the Identification and Classification of Antibody-Mediated Heart Rejection.
Circulation. 2017 Mar 7;135(10):917-935. doi: 10.1161/CIRCULATIONAHA.116.022907. Epub 2017 Feb 1.
3
Updates on antibody-mediated rejection in intestinal transplantation.
World J Transplant. 2016 Sep 24;6(3):564-72. doi: 10.5500/wjt.v6.i3.564.
4
Clinical value of non-HLA antibodies in kidney transplantation: Still an enigma?
Transplant Rev (Orlando). 2016 Oct;30(4):195-202. doi: 10.1016/j.trre.2016.06.001. Epub 2016 Jun 7.
5
2016 Comprehensive Update of the Banff Working Group on Liver Allograft Pathology: Introduction of Antibody-Mediated Rejection.
Am J Transplant. 2016 Oct;16(10):2816-2835. doi: 10.1111/ajt.13909. Epub 2016 Jul 14.
6
Non-HLA antibodies against endothelial targets bridging allo- and autoimmunity.
Kidney Int. 2016 Aug;90(2):280-288. doi: 10.1016/j.kint.2016.03.019. Epub 2016 May 14.
7
Interferon Gamma and Contact-dependent Cytotoxicity Are Each Rate Limiting for Natural Killer Cell-Mediated Antibody-dependent Chronic Rejection.
Am J Transplant. 2016 Nov;16(11):3121-3130. doi: 10.1111/ajt.13865. Epub 2016 Jul 7.
8
Antibody-mediated rejection of the lung: A consensus report of the International Society for Heart and Lung Transplantation.
J Heart Lung Transplant. 2016 Apr;35(4):397-406. doi: 10.1016/j.healun.2016.01.1223. Epub 2016 Feb 10.
9
Donor-specific antibodies and liver transplantation.
Hum Immunol. 2016 Nov;77(11):1063-1070. doi: 10.1016/j.humimm.2016.02.006. Epub 2016 Feb 23.
10
Antibody-Mediated Rejection in Lung Transplantation: Clinical Outcomes and Donor-Specific Antibody Characteristics.
Am J Transplant. 2016 Apr;16(4):1216-28. doi: 10.1111/ajt.13589. Epub 2016 Feb 4.
Zotero 插件