Abbas Khawar, Mubarak Muhammed
Department of Transplant Immunology, Sindh Institute of Urology & Transplantation, Karachi 74200, Sindh, Pakistan.
Javed I. Kazi Department of Histopathology, Sindh Institute of Urology & Transplantation, Karachi 74200, Sindh, Pakistan.
World J Transplant. 2025 Mar 18;15(1):99220. doi: 10.5500/wjt.v15.i1.99220.
The role of antibodies in kidney transplant (KT) has evolved significantly over the past few decades. This role of antibodies in KT is multifaceted, encompassing both the challenges they pose in terms of antibody-mediated rejection (AMR) and the opportunities for improving transplant outcomes through better detection, prevention, and treatment strategies. As our understanding of the immunological mechanisms continues to evolve, so too will the approaches to managing and harnessing the power of antibodies in KT, ultimately leading to improved patient and graft survival. This narrative review explores the multifaceted roles of antibodies in KT, including their involvement in rejection mechanisms, advancements in desensitization protocols, AMR treatments, and their potential role in monitoring and improving graft survival.
在过去几十年中，抗体在肾移植（KT）中的作用发生了显著演变。抗体在肾移植中的这一作用是多方面的，既包括它们在抗体介导的排斥反应（AMR）方面带来的挑战，也包括通过更好的检测、预防和治疗策略改善移植结果的机会。随着我们对免疫机制的理解不断发展，肾移植中管理和利用抗体作用的方法也将不断演进，最终提高患者和移植物的存活率。这篇叙述性综述探讨了抗体在肾移植中的多方面作用，包括它们在排斥机制中的参与、脱敏方案的进展、抗体介导的排斥反应治疗以及它们在监测和改善移植物存活方面的潜在作用。
