Donders Institute, Centre for Cognitive Neuroimaging, Radboud University, 6525 Nijmegen, Netherlands; Lyon Neuroscience Research Center (CRNL), Brain Dynamics and Cognition Team, INSERM U1028, CNRS UMR5292, Université Claude Bernard Lyon 1, UdL, Lyon, France.
Princeton Neuroscience Institute and Department of Psychology, Princeton University , Princeton, New Jersey 08544.
eNeuro. 2017 Mar 27;4(2). doi: 10.1523/ENEURO.0153-16.2017. eCollection 2017 Mar-Apr.
Unraveling how brain regions communicate is crucial for understanding how the brain processes external and internal information. Neuronal oscillations within and across brain regions have been proposed to play a crucial role in this process. Two main hypotheses have been suggested for routing of information based on oscillations, namely communication through coherence and gating by inhibition. Here, we propose a framework unifying these two hypotheses that is based on recent empirical findings. We discuss a theory in which communication between two regions is established by phase synchronization of oscillations at lower frequencies (<25 Hz), which serve as temporal reference frame for information carried by high-frequency activity (>40 Hz). Our framework, consistent with numerous recent empirical findings, posits that cross-frequency interactions are essential for understanding how large-scale cognitive and perceptual networks operate.
解析大脑区域之间如何通讯对于理解大脑如何处理外部和内部信息至关重要。大脑区域内和区域间的神经元振荡被认为在这个过程中起着关键作用。目前有两个主要的假说被提出，用于基于振荡的信息传递，即通过相干性进行通讯和通过抑制进行门控。在这里，我们基于最近的实证发现，提出了一个统一这两个假说的框架。我们讨论了一个理论，即两个区域之间的通讯是通过较低频率（<25 Hz）的振荡的相位同步建立的，较低频率的振荡为高频活动（>40 Hz）携带的信息提供了时间参考框架。我们的框架与许多最近的实证发现一致，它假定跨频相互作用对于理解大规模认知和感知网络的运作方式至关重要。
