Wu Zehong, Li Yuan, Liu Dong, Ma Min, Chen Jianliang, Lin Wenhan
The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518033, P. R. China.
Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou, 510632, P. R. China.
Chem Biodivers. 2017 Jun;14(6). doi: 10.1002/cbdv.201700059. Epub 2017 May 13.
Ten new resorcinol derivatives named hansfordiols A - J (1 - 10) were isolated from the fermentation broth of the sponge-derived fungus Hansfordia sinuosae. High resolution electron ionization mass spectrometry, FT-IR spectroscopy, and NMR techniques were used to elucidate the structures of these compounds, and the absolute configurations were established by the modified Mosher's method and their specific optical rotation. The structures of compounds 8 - 10 were featured with various chlorination at aromatic rings. Their antioxidant activities on ABTS, cytotoxicity on the HCT-8, Bel-7402, BGC-823, A549, and A2780 cell lines, and antibacterial activities were evaluated.
从海绵来源的真菌汉氏弯孢霉（Hansfordia sinuosae）的发酵液中分离出10种新的间苯二酚衍生物，命名为汉氏二醇A - J（1 - 10）。采用高分辨率电子电离质谱、傅里叶变换红外光谱和核磁共振技术对这些化合物的结构进行了阐明，并通过改良的莫舍尔方法及其比旋光度确定了其绝对构型。化合物8 - 10的结构特点是芳环上有各种氯化反应。评估了它们对ABTS的抗氧化活性、对HCT - 8、Bel - 7402、BGC - 823、A549和A2780细胞系的细胞毒性以及抗菌活性。
