Cp*Rh(III)-催化的 C(sp)-H 键对 α,β-不饱和醛和酮的温和加成反应。
Cp*Rh(III)-Catalyzed Mild Addition of C(sp)-H Bonds to α,β-Unsaturated Aldehydes and Ketones.
机构信息
Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, School of Chemistry and Chemical Engineering, Henan Normal University , Xinxiang 453007, China.
Dalian Institute of Chemical Physics, Chinese Academy of Sciences , Dalian 116023, China.
出版信息
Org Lett. 2017 Apr 21;19(8):2086-2089. doi: 10.1021/acs.orglett.7b00690. Epub 2017 Apr 4.
A Rh(III)-catalyzed addition of benzylic C(sp)-H bond to α,β-unsaturated ketones/aldehydes has been realized, leading to efficient synthesis of γ-aryl ketones/aldehydes. This atom-economic reaction proceeded under mild and redox-neutral conditions with a broad substrate scope. Besides benzylic C-H, allylic C-H bonds are also applicable when assisted by O-methyl ketoxime directing groups.
实现了 Rh(III)催化的苄位 C(sp 3 )-H 键与α,β-不饱和酮/醛的加成反应，高效合成了γ-芳基酮/醛。该原子经济性反应在温和且氧化还原中性条件下进行，底物适用范围广泛。当由 O-甲基酮肟导向基团辅助时，烯丙位 C-H 键也适用。
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