促黄体生成素释放激素（LHRH）的金属配合物。电位滴定和光谱研究。

Metal complexes of luteinizing hormone-releasing hormone (LHRH). potentiometric and spectroscopic studies.

作者信息

Gerega K, Kozlowski H, Masiukiewicz E, Pettit L D, Pyburn S, Rzeszotarska B

机构信息

Institute of Chemistry, University of Wroclaw, Poland.

出版信息

J Inorg Biochem. 1988 May;33(1):11-8. doi: 10.1016/0162-0134(88)80030-8.

DOI:10.1016/0162-0134(88)80030-8

PMID:2837530

Abstract

The results are reported of a potentiometric and spectroscopic study of the H+, Cu2+, and Ni2+ complexes of luteinizing hormone-releasing hormone (LHRH, HL) at 25 degrees C and an ionic strength 0.10 mol dm-3 (KNO3), since there is much evidence that the in vivo release of LHRH is influenced by the concentration of copper ions. With Cu2+ the hormone has been shown to behave similarly to the thyrotropin releasing factor, forming a very stable [CuH-1L] complex involving coordination of three nitrogen donors: the Nim atom of the imidazole side chain and the two amido-N atoms of the pyroglutamylhistidyl unit. With Ni2+, coordination proceeds differently to give four nitrogen coordination.

摘要

报告了在25℃和离子强度0.10 mol dm⁻³（KNO₃）条件下，对促黄体生成激素释放激素（LHRH，HL）的H⁺、Cu²⁺和Ni²⁺配合物进行电位滴定和光谱研究的结果，因为有许多证据表明LHRH的体内释放受铜离子浓度的影响。已表明该激素与铜离子形成的配合物与促甲状腺激素释放因子类似，形成非常稳定的[CuH⁻¹L]配合物，涉及三个氮供体的配位：咪唑侧链的Nim原子和焦谷氨酰组氨酰单元的两个酰胺氮原子。而与镍离子配位时，过程有所不同，形成四个氮配位。