Rasla Somwail, Parikh Parag, Hoffmeister Peter, St Amand Amy, Garas Marina K, El Meligy Amr, Minami Taro, Shah Nishant R
Department of Medicine, Memorial Hospital of Rhode Island, Pawtucket, RI; The Warren Alpert Medical School of Brown University.
Department of Medicine, Memorial Hospital of Rhode Island, Pawtucket, RI; College of Pharmacy, University of Rhode Island.
R I Med J (2013). 2017 Apr 3;100(4):33-36.
Loperamide (Imodium) is a non-prescription opioid receptor agonist available over-the-counter for the treatment of diarrhea. When ingested in excessive doses, loperamide can penetrate the blood-brain barrier and is reported to produce euphoria, central nervous system and respiratory depression, and cardiotoxicity. There is an emerging trend in its use among drug abusers for its euphoric effects or for self-treatment of opioid withdrawal. We report a case of ventricular dysrhythmias associated with loperamide abuse in a 28-year-old man who substituted loperamide for the opioids that he used to abuse. [Full article available at http://rimed.org/rimedicaljournal-2017-04.asp].
洛哌丁胺（易蒙停）是一种非处方阿片受体激动剂，可在柜台购买用于治疗腹泻。过量摄入时，洛哌丁胺可穿透血脑屏障，据报道会产生欣快感、中枢神经系统和呼吸抑制以及心脏毒性。在药物滥用者中，因其欣快作用或用于自我治疗阿片类药物戒断，其使用呈上升趋势。我们报告一例28岁男性因滥用洛哌丁胺导致室性心律失常的病例，该患者用洛哌丁胺替代了他过去滥用的阿片类药物。[全文可在http://rimed.org/rimedicaljournal-2017-04.asp获取]
