Wright Tracey B, Punaro Marilynn
Pediatric Rheumatology, University of Texas Southwestern Medical Center.
Rheumatology, Texas Scottish Rite Hospital for Children.
Rheumatology (Oxford). 2017 Apr 1;56(suppl_1):i24-i31. doi: 10.1093/rheumatology/kew447.
Investigations in paediatric SLE contributed significantly to the discovery of the association of type I IFNs with lupus and underscored the potential application of this knowledge by informing the use of glucocorticoid therapy. Recent, promising research reveals biomarkers that may yield more focused clinical monitoring and assessment of response to treatment. This article reviews unique features of paediatric SLE and details important developments in paediatric lupus research.
对儿童系统性红斑狼疮（SLE）的研究为发现I型干扰素与狼疮的关联做出了重大贡献，并通过为糖皮质激素治疗的应用提供信息，突出了这一知识的潜在应用价值。近期有前景的研究揭示了一些生物标志物，这些标志物可能会带来更具针对性的临床监测以及对治疗反应的评估。本文回顾了儿童SLE的独特特征，并详述了儿童狼疮研究中的重要进展。
