Giblett Joel P, Hoole Stephen P
1 Department of Interventional Cardiology, Papworth Hospital, Papworth Everard, Cambridge, UK.
J Cardiovasc Pharmacol Ther. 2017 Jul;22(4):310-315. doi: 10.1177/1074248417702479. Epub 2017 Apr 4.
This review examines the rationale for using remote ischemic conditioning (RIC) in elective percutaneous coronary intervention (PCI) to prevent procedure-related ischemia-reperfusion injury and justifies the importance of periprocedural biomarker elevation following elective PCI as a valid target for RIC. We review the evidence for the use of RIC as a treatment in this setting and document the salutary rules that must be followed to successfully translate RIC for clinical benefit.
本综述探讨了在择期经皮冠状动脉介入治疗(PCI)中使用远程缺血预处理(RIC)以预防与手术相关的缺血再灌注损伤的基本原理,并论证了择期PCI后围手术期生物标志物升高作为RIC有效靶点的重要性。我们回顾了在这种情况下使用RIC作为治疗方法的证据,并记录了为成功将RIC转化为临床益处而必须遵循的有益规则。