Heusch Gerd
1 Institute for Pathophysiology, West German Heart and Vascular Center, University of Essen Medical School, Essen, Germany.
J Cardiovasc Pharmacol Ther. 2017 Jul;22(4):297-301. doi: 10.1177/1074248416687874. Epub 2017 Jan 10.
The existing clinical studies on remote ischemic preconditioning in patients undergoing cardiovascular surgery are critically reviewed, with a focus on infarct size reduction and clinical outcome as end points. Confounders, notably the use of propofol anesthesia are identified. The need for better designed trials with a more targeted approach is emphasized.
对现有的关于心血管手术患者远程缺血预处理的临床研究进行了批判性综述,重点关注以梗死面积缩小和临床结局作为终点。确定了混杂因素,尤其是丙泊酚麻醉的使用。强调需要采用更具针对性的方法进行设计更完善的试验。