Nishimura T, Akasu T
Department of Physiology, Kurume University School of Medicine, Japan.
Neurosci Lett. 1988 Apr 12;86(3):306-10. doi: 10.1016/0304-3940(88)90501-0.
Intracellular recordings were made from neurons in bullfrog sympathetic ganglia. Orthodromic, intracellular and antidromic stimulations evoked recurrent depolarizing responses accompanied by a spontaneous firing of the action potential in type 2 neurons. The depolarizing response elicited by intracellular and antidromic stimulations was selectively blocked by propranolol (1 microM), but not by yohimbine and phenoxybenzamine. Propranolol did not block the 'nicotinic' fast excitatory postsynaptic potential evoked by orthodromic stimulation. These results suggest that excitatory beta-adrenoceptors mediate the recurrent synaptic facilitation of nicotinic transmission in type 2 neurons of bullfrog sympathetic ganglia.
对牛蛙交感神经节中的神经元进行了细胞内记录。在2型神经元中，顺向、细胞内和逆向刺激均诱发了重复性去极化反应，并伴有动作电位的自发放电。细胞内和逆向刺激所引发的去极化反应可被普萘洛尔（1微摩尔）选择性阻断，但不能被育亨宾和酚苄明阻断。普萘洛尔并不阻断顺向刺激所诱发的“烟碱样”快速兴奋性突触后电位。这些结果表明，兴奋性β-肾上腺素能受体介导了牛蛙交感神经节2型神经元中烟碱样传递的重复性突触易化作用。
