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三种金属氧化物纳米颗粒及其溶解态金属离子的抗菌活性比较

Antibacterial Activity Comparison of Three Metal Oxide Nanoparticles and their Dissolved Metal Ions.

作者信息

Qin Qiang, Li Jiayin, Wang Jianbing

出版信息

Water Environ Res. 2017 Apr 1;89(4):378-383. doi: 10.2175/106143017X14839994523262.

DOI:10.2175/106143017X14839994523262
PMID:28377007
Abstract

The potential ecotoxicity of three metal-oxide nanoparticles (NPs) toward Escherichia coli (E. coli) was investigated, including titanium dioxide (TiO2), copper oxide (CuO), and zinc oxide (ZnO). The true particle sizes of NPs in medium were significantly larger than the advertised sizes. Bacterial toxicity tests showed that the three NPs were harmful to varying degrees. The toxicity of CuO toward E. coli increased with the increasing concentration of CuO. The toxicity of ZnO and TiO2 toward E. coli was highest at NP concentration of 5 and 20 mg/L, respectively, but decreased when the NP concentration was higher, which is closely related with the nanoparticle sizes. Ion toxicity further demonstrated that dissolved metal ions were also responsible for the toxicity of CuO and ZnO. These results highlight the need for caution during the use and disposal of such manufactured nanomaterials to prevent unintended environmental impacts.

摘要

研究了三种金属氧化物纳米颗粒(NPs)对大肠杆菌(E. coli)的潜在生态毒性,包括二氧化钛(TiO2)、氧化铜(CuO)和氧化锌(ZnO)。介质中纳米颗粒的真实粒径明显大于标称尺寸。细菌毒性测试表明,这三种纳米颗粒均有不同程度的危害。CuO对大肠杆菌的毒性随CuO浓度的增加而增加。ZnO和TiO2对大肠杆菌的毒性分别在NP浓度为5和20 mg/L时最高,但当NP浓度更高时毒性降低,这与纳米颗粒的尺寸密切相关。离子毒性进一步表明,溶解的金属离子也对CuO和ZnO的毒性有影响。这些结果突出了在使用和处置此类人造纳米材料时需谨慎行事,以防止意外的环境影响。

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