Hicks S J, Edwards D, Shearer B M
Christchurch Branch Family Planning Clinic.
N Z Med J. 1987 Oct 28;100(834):647-9.
A five-fold increase in the incidence of histologically-proven cervical intraepithelial neoplasia grade 3 (CIN3) was observed for patients attending the Christchurch family planning clinic in 1985 compared with the preceding three years. There were 51 new cases in 1985 and a yearly average of 9.3 between 1982 and 1984. There was an increase also in cervical smears showing evidence of human papillomavirus (HPV) infection. The time interval between the last normal smear and the diagnosis of CIN3 was short, averaging 2.3 years. CIN3 patients were young (average 28.9 years); they had a high average number of sexual partners (10.1). These findings support the theory of a sexually transmitted precursor to the development of CIN3. The 1985 surge in CIN3 may reflect an increased prevalence of this oncogenic agent. The aim of screening is to prevent invasive cervical carcinoma. Annual smears should therefore be considered for young sexually-active women in view of the short time interval between normal smears and the development of CIN3.
与前三年相比，1985年就诊于克赖斯特彻奇计划生育诊所的患者中，经组织学证实的宫颈上皮内瘤变3级（CIN3）发病率增加了五倍。1985年有51例新病例，1982年至1984年的年平均病例数为9.3例。显示人乳头瘤病毒（HPV）感染迹象的宫颈涂片检查结果也有所增加。从最后一次正常涂片到CIN3诊断之间的时间间隔很短，平均为2.3年。CIN3患者较为年轻（平均28.9岁）；她们的性伴侣平均数量较多（10.1个）。这些发现支持了CIN3发展存在性传播前驱因素的理论。1985年CIN3病例的激增可能反映了这种致癌因子患病率的上升。筛查的目的是预防浸润性宫颈癌。因此，鉴于从正常涂片到CIN3发展的时间间隔较短，对于年轻的性活跃女性应考虑每年进行涂片检查。
