França Gustavo S, Hinske Ludwig C, Galante Pedro A F, Vibranovski Maria D
Departamento de Genética e Biologia Evolutiva, Universidade de São Paulo São Paulo, Brazil.
Department of Anesthesiology, Clinic of the University of Munich, Ludwig Maximilian University of Munich Munich, Germany.
Front Genet. 2017 Mar 21;8:34. doi: 10.3389/fgene.2017.00034. eCollection 2017.
Eukaryotic genomes frequently exhibit interdependency between transcriptional units, as evidenced by regions of high gene density. It is well recognized that vertebrate microRNAs (miRNAs) are usually embedded in those regions. Recent work has shown that the genomic context is of utmost importance to determine miRNA expression in time and space, thus affecting their evolutionary fates over long and short terms. Consequently, understanding the inter- and intraspecific changes on miRNA genomic architecture may bring novel insights on the basic cellular processes regulated by miRNAs, as well as phenotypic evolution and disease-related mechanisms.
真核生物基因组经常表现出转录单元之间的相互依赖性，高基因密度区域就是证明。脊椎动物的微小RNA（miRNA）通常就嵌入在这些区域，这一点已得到广泛认可。最近的研究表明，基因组背景对于确定miRNA在时间和空间上的表达至关重要，从而在长期和短期内影响它们的进化命运。因此，了解miRNA基因组结构的种间和种内变化，可能会为miRNA调控的基本细胞过程、表型进化和疾病相关机制带来新的见解。
