Laboratory of Gene Regulation Research, Graduate School of Biological Sciences, Nara Institute of Science and Technology (NAIST), 8916-5, Takayama, Ikoma, Nara 630-0192, Japan.
Life Science Tokyo Advanced Research Center (L-StaR), Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41, Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.
Sci Rep. 2017 Apr 5;7:46024. doi: 10.1038/srep46024.
Perineuronal nets (PNNs), proteoglycan-rich extracellular matrix structures, are thought to be expressed around inhibitory neurons and contribute to critical periods of brain function and synaptic plasticity. However, in some specific brain regions such as the amygdala, PNNs were predominantly expressed around excitatory neurons. These neurons were recruited during auditory fear conditioning and memory retrieval. Indeed, the activation of PNN-expressing excitatory neurons predicted cognitive performance.
周围神经毡（PNNs）是富含蛋白聚糖的细胞外基质结构，被认为表达于抑制性神经元周围，并对大脑功能和突触可塑性的关键时期有贡献。然而，在一些特定的脑区，如杏仁核，PNNs 主要表达于兴奋性神经元周围。这些神经元在听觉恐惧条件反射和记忆检索中被募集。事实上，表达 PNN 的兴奋性神经元的激活可以预测认知表现。
