Kajiura Y, Tsukiyama I, Ogino T, Akine Y, Egawa S
Dept. of Radiation Therapy, National Cancer Center.
Gan To Kagaku Ryoho. 1988 Apr;15(4 Pt 2-2):1393-400.
Local response of hyperthermia for soft tissue and bone tumors was investigated. Ten tumors were superficial tumors and 16 were deep seated tumors; 9 tumors were malignant fibrous histiocytoma, 5 were liposarcoma, 4 were neurogenic and 3 were myogenic sarcoma. The other five tumors were an angiosarcoma, a malignant mesenchymoma, an Ewing's sarcoma, a chordoma and an osteosarcoma. Some 23 tumors were heated in combination with radiation therapy, and 3 were combined with arterial infusion of ADR. Four of 10 superficial tumors disappeared (CR), and, 2 of 10 signified PR. Only one of 16 deep seated tumors showed CR, 3 were PR and 12 showed no response. But 4 of 12 tumors without regression in tumor volume indicated coagulation necrosis owing to histological examinations, and 5 of 12 were regarded as the same response from hypodensity area with CT examination after hyperthermia. Local response rate of of superficial tumors was 60% and that of deep-seated tumors was 81.4%.
对软组织和骨肿瘤热疗的局部反应进行了研究。10个肿瘤为浅表肿瘤，16个为深部肿瘤；9个肿瘤为恶性纤维组织细胞瘤，5个为脂肪肉瘤，4个为神经源性肉瘤，3个为肌源性肉瘤。另外5个肿瘤分别为血管肉瘤、恶性间叶瘤、尤因肉瘤、脊索瘤和骨肉瘤。约23个肿瘤与放射治疗联合加热，3个与阿霉素动脉灌注联合使用。10个浅表肿瘤中有4个消失（完全缓解），10个中有2个显示部分缓解。16个深部肿瘤中只有1个显示完全缓解，3个为部分缓解，12个无反应。但12个肿瘤体积无缩小的病例中，经组织学检查有4个显示凝固性坏死，热疗后CT检查发现12个中有5个低密度区有相同反应。浅表肿瘤的局部缓解率为60%，深部肿瘤为81.4%。
