Department of Internal Medicine-Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan 250117, China.
Dean's Office, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan 250117, China.
Future Oncol. 2017 Jul;13(16):1395-1404. doi: 10.2217/fon-2017-0099. Epub 2017 Apr 6.
Conducting postmastectomy radiation therapy (PMRT) for breast cancer patients with one to three positive lymph nodes is still controversial.
Propensity score matching analysis was applied to balance the clinical baseline characteristics of patients. Cox proportional hazard analysis was used to analyze the survival prognosis factors and perform subgroup analysis.
There was no statistical difference in overall survival and cancer-specific survival rates (all, p > 0.05) between the PMRT and non-PMRT groups. However, for subgroup patients with tumor size ≥5 cm and the number of positive lymph nodes = 3, PMRT showed a significant survival benefit.
PMRT can improve overall survival and cancer-specific survival only in breast cancer patients whose tumor size is larger than 5 cm and with three positive lymph nodes.
对 1-3 个阳性淋巴结的乳腺癌患者进行乳房切除术（PMRT）仍存在争议。
采用倾向评分匹配分析平衡患者的临床基线特征。采用 Cox 比例风险分析对生存预后因素进行分析，并进行亚组分析。
PMRT 组与非 PMRT 组的总生存率和癌症特异性生存率（均，p>0.05）无统计学差异。然而，对于肿瘤大小≥5cm 和阳性淋巴结数=3 的亚组患者，PMRT 显示出显著的生存获益。
PMRT 仅能改善肿瘤大小大于 5cm 且有 3 个阳性淋巴结的乳腺癌患者的总生存率和癌症特异性生存率。
