Howard J R, Veach S R, DeVaney K, Walsh T, Cotelingam J D, Johnson B E
National Cancer Institute-Navy Medical Oncology Branch, Department of Medicine, Naval Hospital, Bethesda, MD 20814.
Cancer. 1988 Jul 15;62(2):436-9. doi: 10.1002/1097-0142(19880715)62:2<436::aid-cncr2820620231>3.0.co;2-9.
The development of non-small cell lung cancer in patients successfully treated for small cell lung cancer has been previously described. Many of these non-small cell tumors appear to be second primary lung tumors. However, the development of second primary small cell lung cancers has not been clearly delineated. In this report, a patient with limited stage small cell lung cancer who had a complete response to chemotherapy plus chest radiotherapy and remained cancer-free for 8 years is described. Small cell lung cancer developed in this patient's contralateral lung with no evidence of recurrence at the original primary site. Clinical evidence suggests that a second primary small cell lung cancer developed in this patient.
小细胞肺癌患者成功治疗后发生非小细胞肺癌的情况此前已有描述。这些非小细胞肿瘤中的许多似乎是第二原发性肺癌。然而，第二原发性小细胞肺癌的发生情况尚未明确界定。在本报告中，描述了一名局限期小细胞肺癌患者，该患者对化疗加胸部放疗完全缓解且8年无癌。该患者对侧肺发生了小细胞肺癌，原原发部位无复发迹象。临床证据表明该患者发生了第二原发性小细胞肺癌。
