Torihata Sayaka, Mukai Takao, Uchihashi Takayuki, Matsunaga Kazuhide, Miki Hitomi, Yasumoto Mio, Yasutake Natsumi, Ashida Ayana, Enomoto Akifumi, Hamada Suguru, Ashida Takashi
Department of Oral and Maxillofacial Surgery, Kindai University Hospital.
Rinsho Ketsueki. 2017;58(3):197-203. doi: 10.11406/rinketsu.58.197.
In the present study, we compared the incidence and severity of oral mucositis among patients undergoing allogeneic hematopoietic stem cell transplantation after fludarabine-based regimens with busulfan 12.8 mg/kg (FB12.8), with busulfan less than or equal to 9.6 mg/kg (FB9.6), and with melphalan 140 mg/m (FM). The incidence of oral mucositis after FB12.8 was the highest among these 3 groups. After FM, all of the patients had developed oral mucositis by day 7. The mean disease duration of oral mucositis after FB12.8 was 13.5 days, whereas the mean disease duration after FM was 24.9 days, and was significantly prolonged as compared to that after FB12.8 (p=0.0009). The incidence of severe oral mucositis (grade 3) after FM was significantly higher than that after FB12.8 (p=0.03). As stated above, although the incidence of oral mucositis after FB12.8 was higher than that after FM, oral mucositis after FB12.8 showed improvement relatively quickly without deterioration. In contrast, the higher incidence of severe oral mucositis and the delay in resolution of mucositis after FM were remarkable.
在本研究中，我们比较了接受基于氟达拉滨方案的异基因造血干细胞移植患者中，使用12.8mg/kg白消安（FB12.8）、小于或等于9.6mg/kg白消安（FB9.6）以及使用140mg/m美法仑（FM）时口腔黏膜炎的发生率和严重程度。在这三组中，FB12.8组口腔黏膜炎的发生率最高。FM组中，所有患者在第7天均出现了口腔黏膜炎。FB12.8组口腔黏膜炎的平均病程为13.5天，而FM组的平均病程为24.9天，与FB12.8组相比显著延长（p = 0.0009）。FM组严重口腔黏膜炎（3级）的发生率显著高于FB12.8组（p = 0.03）。如上所述，尽管FB12.8组口腔黏膜炎的发生率高于FM组，但FB12.8组的口腔黏膜炎改善相对较快且无恶化。相比之下，FM组严重口腔黏膜炎的发生率较高且黏膜炎消退延迟较为明显。
