伴有脑出血的脑动脉粥样硬化伴皮质下梗死和白质脑病（CADASIL）：两例新病例
CADASIL: two new cases with intracerebral hemorrhage.
作者信息
Zhang Chen, Li Wei, Li Shaowu, Niu Songtao, Wang Xingao, Tang Hefei, Yu Xueying, Chen Bin, Shi Yuzhi, Chen Qihua, Guo Liying, Pan Yunzhu, Wang Yilong, Zhang Zaiqiang
机构信息
Department of Neurology Beijing Tiantan Hospital Capital Medical University Beijing 100050 China.
Beijing Neurosurgical Institute Capital Medical University Beijing 100050 China.
出版信息
Ann Clin Transl Neurol. 2017 Mar 7;4(4):266-271. doi: 10.1002/acn3.400. eCollection 2017 Apr.
Whether cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a risk factor for spontaneous intracerebral hemorrhage (ICH) and influences outcomes remains unclear. In this study, we report two cases of CADASIL presenting with cerebral hemorrhages. These cases suggest that a CADASIL vasculopathy by itself mainly results in ICH, as indicated by slight vascular risk factors and prominent neuroimaging abnormalities, suggesting that CADASIL should be considered a risk factor for ICH. Interestingly, decreased perihematomal edema was noted in ICH patients with CADASIL in this study.
伴有皮质下梗死和白质脑病的常染色体显性遗传性脑动脉病（CADASIL）是否为自发性脑出血（ICH）的危险因素以及是否影响预后仍不清楚。在本研究中，我们报告了2例表现为脑出血的CADASIL病例。这些病例表明，CADASIL血管病变本身主要导致脑出血，轻微的血管危险因素和明显的神经影像学异常表明了这一点，提示CADASIL应被视为ICH的一个危险因素。有趣的是，本研究中患有CADASIL的ICH患者血肿周围水肿减轻。
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