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X射线相衬成像中透镜耦合探测器的几何校准与校正

Geometric calibration and correction for a lens-coupled detector in x-ray phase-contrast imaging.

作者信息

George Alex, Chen Peter Y, Morales-Martinez Alejandro, Panna Alireza, Gomella Andrew A, Bennett Eric E, Wen Han

机构信息

National Institutes of Health , National Heart, Lung and Blood Institute, Biochemistry and Biophysics Center, Imaging Physics Laboratory, Bethesda, Maryland, United States.

出版信息

J Med Imaging (Bellingham). 2017 Jan;4(1):013507. doi: 10.1117/1.JMI.4.1.013507. Epub 2017 Mar 24.

Abstract

A lens-coupled x-ray camera with a tilted phosphor collects light emission from the x-ray illuminated (front) side of phosphor. Experimentally, it has been shown to double x-ray photon capture efficiency and triple the spatial resolution along the phosphor tilt direction relative to the same detector at normal phosphor incidence. These characteristics benefit grating-based phase-contrast methods, where linear interference fringes need to be clearly resolved. However, both the shallow incident angle on the phosphor and lens aberrations of the camera cause geometric distortions. When tiling multiple images of limited vertical view into a full-field image, geometric distortion causes blurring due to image misregistration. Here, we report a procedure of geometric correction based on global polynomial transformation of image coordinates. The corrected image is equivalent to one obtained with a single full-field flat panel detector placed at the sample plane. In a separate evaluation scan, the position deviations in the horizontal and vertical directions were reduced from 0.76 and 0.028 mm, respectively, to 0.006 and 0.009 mm, respectively, by the correction procedure, which were below the 0.028-mm pixel size of the imaging system. In a demonstration of a phase-contrast imaging experiment, the correction reduced blurring of small structures.

摘要

一种带有倾斜磷光体的透镜耦合X射线相机,可收集来自磷光体X射线照射(正面)侧的光发射。实验表明,相对于正常磷光体入射时的同一探测器,它能使X射线光子捕获效率提高一倍,并使沿磷光体倾斜方向的空间分辨率提高两倍。这些特性有利于基于光栅的相衬方法,在该方法中需要清晰分辨线性干涉条纹。然而,磷光体上的浅入射角和相机的透镜像差都会导致几何畸变。当将有限垂直视野的多个图像拼接成全场图像时,几何畸变会因图像配准错误而导致模糊。在此,我们报告一种基于图像坐标全局多项式变换的几何校正程序。校正后的图像等同于使用放置在样品平面的单个全场平板探测器获得的图像。在一次单独的评估扫描中,通过校正程序,水平和垂直方向的位置偏差分别从0.76毫米和0.028毫米降至0.006毫米和0.009毫米,均低于成像系统0.028毫米的像素尺寸。在一次相衬成像实验演示中,校正减少了小结构的模糊。

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