一种用于从224Ra生产212Pb和212Bi的改进型发生器。

An improved generator for the production of 212Pb and 212Bi from 224Ra.

作者信息

Atcher R W, Friedman A M, Hines J J

机构信息

Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland.

出版信息

Int J Rad Appl Instrum A. 1988;39(4):283-6. doi: 10.1016/0883-2889(88)90016-0.

DOI:10.1016/0883-2889(88)90016-0

PMID:2838433

Abstract

We have developed an improved generator for the production of the alpha emitting radionuclide 212Bi and its parent, 212Pb. These radionuclides are well suited to use as radiotherapeutic agents due to their relatively short half lives and appropriate particle particle emissions. The parent, 224Ra, is available from a long-lived parent and can be isolated on a generator which produces the daughters in good yield and low breakthrough. The 212Bi can be eluted by itself or in equilibrium with its parent.

摘要

我们已经开发出一种改进的发生器，用于生产发射α粒子的放射性核素212Bi及其母体212Pb。由于这些放射性核素半衰期相对较短且粒子发射合适，它们非常适合用作放射治疗剂。母体224Ra可从一种长寿命母体获得，并可在一个发生器上分离出来，该发生器能高产率且低突破地产生子体。212Bi可以单独洗脱，也可以与其母体处于平衡状态洗脱。