Vanderbilt Brain Institute and Division of Nephrology, Vanderbilt University School of Medicine, Nashville, TN, USA.
Department of Biomedical Informatics, Vanderbilt University, Nashville, TN, USA.
Mol Brain. 2017 Apr 6;10(1):11. doi: 10.1186/s13041-017-0291-1.
A-to-I RNA editing is an important process for generating molecular diversity in the brain through modification of transcripts encoding several proteins important for neuronal signaling. We investigated the relationships between the extent of editing at multiple substrate transcripts (5HT2C, MGLUR4, CADPS, GLUR2, GLUR4, and GABRA3) in brain tissue obtained from adult humans and rhesus macaques. Several patterns emerged from these studies revealing conservation of editing across primate species. Additionally, variability in the human population allows us to make novel inferences about the co-regulation of editing at different editing sites and even across different brain regions.
A-to-I RNA 编辑是通过修饰编码几种对神经元信号传递至关重要的蛋白质的转录本，从而在大脑中产生分子多样性的重要过程。我们研究了从成年人类和恒河猴脑组织中获得的多个底物转录本（5HT2C、MGLUR4、CADPS、GLUR2、GLUR4 和 GABRA3）的编辑程度之间的关系。这些研究揭示了跨灵长类物种编辑的保守性，出现了几种模式。此外，人类群体的变异性使我们能够对不同编辑位点甚至不同脑区的编辑进行新的推断。
