头颈部黏膜恶性黑色素瘤的预后因素

Prognostic factors in head and neck mucosal malignant melanoma.

作者信息

Çomoğlu Şenol, Polat Beldan, Çelik Mehmet, Şahin Bayram, Enver Necati, Keleş Meryem Nesil, Sarı Şule Öztürk

机构信息

University of Istanbul, Istanbul Medical Faculty Department of Otorhinolaryngology-Head and Neck Surgery, Istanbul, Turkey.

Marmara University, Department of Otorhinolaryngology-Head and Neck Surgery, Istanbul, Turkey.

出版信息

Auris Nasus Larynx. 2018 Feb;45(1):135-142. doi: 10.1016/j.anl.2017.03.016. Epub 2017 Apr 3.

DOI:10.1016/j.anl.2017.03.016

PMID:28385366

Abstract

OBJECTIVE

Primary mucosal malignant melanoma of the head and neck (HN-PMMM) is an aggressive and uncommon neoplasm. Herein, we present a series of 33 patients and the results of treatment, and aimed to determine prognostic factors in HN-PMMM.

METHODS

Patients who were diagnosed as having HN-PMMM in our reference hospital, between 2005 and 2014 were evaluated. Thirty-three of these patients who had follow-up data were included. Surgical margin status was extracted from the original pathology reports. Archived materials were retrieved for the histopathologic findings: ulceration, necrosis, lymphovascular invasion, perineural invasion, pigmentation, and presence of an in situ component. Mitotic activity was evaluated using phosphohistone H3 (PHH3) immunohistochemical staining.

RESULTS

We found an association of PHH3 mitotic activity with overall survival in a univariate analysis and to our knowledge, this is the first report among the available case series of HN-PMMM to evaluate mitotic activity using immunohistochemical staining. We also investigated the relationship between multicentricity and locoregional recurrence, which the authors believe is also a first.

CONCLUSION

PHH3 mitotic activity can be used a prognostic factor for head and neck mucosal malignant melanoma.

摘要

目的

头颈部原发性黏膜恶性黑色素瘤（HN-PMMM）是一种侵袭性且罕见的肿瘤。在此，我们报告一组33例患者及其治疗结果，旨在确定HN-PMMM的预后因素。

方法

对2005年至2014年期间在我院被诊断为HN-PMMM的患者进行评估。纳入其中33例有随访数据的患者。手术切缘状态从原始病理报告中提取。检索存档材料以获取组织病理学结果：溃疡、坏死、淋巴管侵犯、神经周侵犯、色素沉着以及原位成分的存在情况。使用磷酸化组蛋白H3（PHH3）免疫组织化学染色评估有丝分裂活性。