进行性核上性麻痹中的GABA光谱与远距离干扰效应：一项初步研究。

GABA spectra and remote distractor effect in progressive supranuclear palsy: A pilot study.

作者信息

Bonnet C, Rusz J, Hanuška J, Dezortová M, Jírů F, Sieger T, Jech R, Klempíř J, Roth J, Bezdíček O, Serranová T, Dušek P, Uher T, Flammand-Roze C, Hájek M, Růžička E

机构信息

Department of Neurology, Center of Clinical Neuroscience, Charles University, First Faculty of Medicine, General University Hospital, Kateřinská 30, Prague 2, 12000 Prague, Czech Republic; Department of Neurology, Pitié-Salpêtrière Hospital, AP-HP, 75013 Paris, France.

Department of Neurology, Center of Clinical Neuroscience, Charles University, First Faculty of Medicine, General University Hospital, Kateřinská 30, Prague 2, 12000 Prague, Czech Republic; Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University, Prague, Czech Republic.

出版信息

Rev Neurol (Paris). 2017 Apr;173(4):225-229. doi: 10.1016/j.neurol.2017.03.007. Epub 2017 Apr 3.

DOI:10.1016/j.neurol.2017.03.007

PMID:28385472

Abstract

Disturbances of the gamma-aminobutyric-acid (GABA) system have been suspected of contributing to the pathophysiology of progressive supranuclear palsy (PSP). The ability to rapidly resolve competitive action decisions, such as shifting the gaze to one particular stimulus rather than another, can be predicted by the concentration of GABA in the region of the frontal cortex relevant to eye movements. For this reason, our study measured GABA levels in seven PSP patients and eight healthy controls, using proton magnetic resonance spectroscopy, and assessed the relationship of these measurements to the remote distractor effect (RDE), an eye-movement paradigm investigating competitive action decisions. No significant differences were found in either frontal-eye-field GABA levels or RDE between PSP patients and controls.

摘要

γ-氨基丁酸（GABA）系统紊乱被怀疑与进行性核上性麻痹（PSP）的病理生理学有关。快速解决竞争性动作决策的能力，比如将目光转向一个特定刺激而非另一个，可通过与眼球运动相关的额叶皮质区域中GABA的浓度来预测。因此，我们的研究使用质子磁共振波谱法测量了7名PSP患者和8名健康对照者的GABA水平，并评估了这些测量值与远程干扰效应（RDE）之间的关系，RDE是一种研究竞争性动作决策的眼球运动范式。PSP患者和对照组在额叶眼区GABA水平或RDE方面均未发现显著差异。