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更多 GABA,更少分心:运动决策速度的神经化学预测指标。

More GABA, less distraction: a neurochemical predictor of motor decision speed.

机构信息

Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, UK.

出版信息

Nat Neurosci. 2010 Jul;13(7):825-7. doi: 10.1038/nn.2559. Epub 2010 May 30.

DOI:10.1038/nn.2559
PMID:20512136
Abstract

People vary markedly in the efficiency with which they can resolve competitive action decisions, even simple ones such as shifting gaze to one stimulus rather than another. We found that an individual's ability to rapidly resolve such competition is predicted by the concentration of GABA, the main inhibitory neurotransmitter, in a region of frontal cortex that is relevant for eye movements, but not in a control region (occipital cortex).

摘要

人们在解决竞争行为决策的效率上存在显著差异,即使是像将目光从一个刺激转移到另一个刺激这样简单的决策也是如此。我们发现,个体快速解决这种竞争的能力可以通过与眼球运动相关的额前皮质区域中 GABA(主要的抑制性神经递质)的浓度来预测,而不是通过控制区域(枕叶皮质)来预测。

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A fragile balance: perturbation of GABA mediated circuit in prefrontal cortex generates high intraindividual performance variability.
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