Centre for Endocrine Surgery, University College London Hospital, London, United Kingdom.
Centre for Endocrine Surgery, University College London Hospital, London, United Kingdom.
Mol Cell Endocrinol. 2018 Jul 5;469:85-91. doi: 10.1016/j.mce.2017.03.032. Epub 2017 Apr 4.
Pancreatic neuroendocrine tumours are a diverse group of neoplasms with an increasingly well-defined genomic basis. Despite this, much of what drives this disease is still unknown and epigenetic influences represent the next tier of gene, and hence disease modifiers that are of unquestionable importance. Moreover, they are of arguably more significance than the genes themselves given their malleable nature and potential to be exploited for not only diagnosis and prognosis, but also therapy. This review summarises what is known regarding the key epigenetic modifiers of disease through the domains of diagnosis, prognosis and treatment.
胰腺神经内分泌肿瘤是一组具有不同表型的肿瘤，其具有日益明确的基因组基础。尽管如此，驱动这种疾病的许多因素仍然未知，而表观遗传影响代表了下一个层次的基因，因此是疾病修饰因子，这具有毋庸置疑的重要性。此外，鉴于其可塑性质以及在诊断、预后和治疗方面的应用潜力，它们可能比基因本身更为重要。本文通过诊断、预后和治疗领域，总结了已知的疾病关键表观遗传修饰因子。
