Wing Chung Chang, MRCPsych, FHKCPsych, Department of Psychiatry, Queen Mary Hospital and State Key Laboratory of Brain and Cognitive Sciences, the University of Hong Kong, Hong Kong; Vivian Wing Yan Kwong, MPsyMed, Emily Sin Kei Lau, MSocSc(CP), Department of Psychiatry, Queen Mary Hospital, Hong Kong; Hon Cheong So, MBBS, PhD, School of Biomedical Sciences, the Chinese University of Hong Kong, Hong Kong; Corine Sau Man Wong MsocSc, Gloria Hoi Kei Chan, MSSc(CP), Olivia Tsz Ting Jim, BSocSc, Christy Lai Ming Hui, PhD, Department of Psychiatry, Queen Mary Hospital, Hong Kong; Sherry Kit Wa Chan, MRCPsych, FHKCPsych, Department of Psychiatry, Queen Mary Hospital and State Key Laboratory of Brain and Cognitive Sciences, the University of Hong Kong Hong Kong; Edwin Ho Ming Lee, MRCPsych, FHKCPsych, Department of Psychiatry, Queen Mary Hospital, Hong Kong; Eric Yu Hai Chen, MD, Department of Psychiatry, Queen Mary Hospital and State Key Laboratory of Brain and Cognitive Sciences, the University of Hong Kong, Hong Kong
Wing Chung Chang, MRCPsych, FHKCPsych, Department of Psychiatry, Queen Mary Hospital and State Key Laboratory of Brain and Cognitive Sciences, the University of Hong Kong, Hong Kong; Vivian Wing Yan Kwong, MPsyMed, Emily Sin Kei Lau, MSocSc(CP), Department of Psychiatry, Queen Mary Hospital, Hong Kong; Hon Cheong So, MBBS, PhD, School of Biomedical Sciences, the Chinese University of Hong Kong, Hong Kong; Corine Sau Man Wong MsocSc, Gloria Hoi Kei Chan, MSSc(CP), Olivia Tsz Ting Jim, BSocSc, Christy Lai Ming Hui, PhD, Department of Psychiatry, Queen Mary Hospital, Hong Kong; Sherry Kit Wa Chan, MRCPsych, FHKCPsych, Department of Psychiatry, Queen Mary Hospital and State Key Laboratory of Brain and Cognitive Sciences, the University of Hong Kong Hong Kong; Edwin Ho Ming Lee, MRCPsych, FHKCPsych, Department of Psychiatry, Queen Mary Hospital, Hong Kong; Eric Yu Hai Chen, MD, Department of Psychiatry, Queen Mary Hospital and State Key Laboratory of Brain and Cognitive Sciences, the University of Hong Kong, Hong Kong.
Br J Psychiatry. 2017 Jul;211(1):37-44. doi: 10.1192/bjp.bp.117.198929. Epub 2017 Apr 6.
Evidence indicates that the positive effects of 2-year early intervention services for psychosis are not maintained after service withdrawal. Optimal duration of early intervention in sustaining initial improved outcomes remains to be determined.To examine the sustainability of the positive effects of an extended, 3-year, early intervention programme for patients with first-episode psychosis (FEP) after transition to standard care.A total of 160 patients, who had received a 2-year early intervention programme for FEP, were enrolled to a 12-month randomised-controlled trial (ClinicalTrials.gov: NCT01202357) comparing a 1-year extension of the early intervention (3-year specialised treatment) with step-down care (2-year specialised treatment). Participants were followed up and reassessed 2 and 3 years after inclusion to the trial.There were no significant differences between the treatment groups in outcomes on functioning, symptom severity and service use during the post-trial follow-up period.The therapeutic benefits achieved by the extended, 3-year early intervention were not sustainable after termination of the specialised service.
证据表明，精神病的 2 年早期干预服务的积极效果在服务退出后无法维持。维持初始改善结果的最佳早期干预持续时间仍有待确定。为了研究在过渡到标准护理后，对首发精神病（FEP）患者进行为期 3 年的扩展早期干预计划的积极效果的可持续性。共有 160 名接受过为期 2 年的 FEP 早期干预计划的患者参加了一项为期 12 个月的随机对照试验（ClinicalTrials.gov：NCT01202357），该试验比较了为期 1 年的早期干预（3 年专业治疗）与逐步减少护理（2 年专业治疗）。在试验纳入后 2 年和 3 年对参与者进行了随访和重新评估。在试验后随访期间，治疗组在功能、症状严重程度和服务使用方面的结果没有差异。在专业服务终止后，扩展的 3 年早期干预所取得的治疗效益无法持续。
