Dietl M, Palacios J M
Preclinical Research, Sandoz Ltd., Basle, Switzerland.
J Recept Res. 1988;8(1-4):521-32. doi: 10.3109/10799898809049009.
Recent studies on the neurotransmitter organization of the basal ganglia and forebrain in lower vertebrates suggest that, in contrast to the old concepts of the phylogeny of the brain, there are many similarities between the chemical organization of the brain throughout evolution. By examining neurotransmitter receptors using in vitro autoradiography we have attempted to further our understanding of the evolution of the brain. Receptors enriched in different parts of the basal ganglia in mammals appear to be also enriched in the homologous areas in lower vertebrates. Thus, for example, dopamine and muscarinic receptors, but not serotonin-1A, are enriched in the paleostriatum augmentatum while GABA/benzodiazepine receptors are enriched in the paleostriatum primitivum corresponding with their localization to the caudate-putamen and globus pallidus respectively. Our results support the concept of a more conservative evolution of the vertebrate brain and demonstrate the usefulness of receptor autoradiography in the understanding of brain evolution.
近期对低等脊椎动物基底神经节和前脑神经递质组织的研究表明，与以往关于脑系统发育的旧观念相反，在整个进化过程中，脑的化学组织存在许多相似之处。通过使用体外放射自显影技术检测神经递质受体，我们试图进一步了解脑的进化。在哺乳动物基底神经节不同部位富集的受体，似乎在低等脊椎动物的同源区域也有富集。例如，多巴胺和毒蕈碱受体，而非5-羟色胺1A受体，在苍白球增大部富集，而GABA/苯二氮䓬受体在原始苍白球富集，这分别与它们在尾状核-壳核和苍白球的定位相对应。我们的结果支持脊椎动物脑进化更为保守的观点，并证明了受体放射自显影在理解脑进化方面的有用性。
