帕金森病中影响食管动力的神经递质变化的证据。
Evidence for a change in neurotransmitter affecting oesophageal motility in Parkinson's disease.
作者信息
Bramble M G, Cunliffe J, Dellipiani A W
出版信息
J Neurol Neurosurg Psychiatry. 1978 Aug;41(8):709-12. doi: 10.1136/jnnp.41.8.709.
Abstract
In a study of oesophageal motility in 20 patients with Parkinson's disease, intravenous atropine produced marked disruption of co-ordination in response to swallows, when compared with control subjects. This suggests that cholinergic rather than dopaminergic mechanisms are more important in the control of swallowing in patients with Parkinsonism. No conclusive evidence of peripheral dopamine depletion or autonomic neuropathy was found, although minor changes suggestive of the former were found in severely affected patients.
摘要
在一项针对20名帕金森病患者食管运动功能的研究中，与对照组相比，静脉注射阿托品后，吞咽反应的协调性受到显著破坏。这表明胆碱能机制而非多巴胺能机制在帕金森病患者吞咽控制中更为重要。尽管在病情严重的患者中发现了一些提示前者（外周多巴胺耗竭）的轻微变化，但未找到外周多巴胺耗竭或自主神经病变的确切证据。
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