1Department of Neuroradiology, ASST Grande Ospedale Metropolitano Niguarda, Milan; and.
2Department of Radiology, Policlinico Universitario "Agostino Gemelli," Rome,Italy.
J Neurosurg. 2018 Apr;128(4):1037-1043. doi: 10.3171/2016.11.JNS161937. Epub 2017 Apr 7.
OBJECTIVE In this single-center series, the authors retrospectively evaluated the effectiveness, safety, and midterm follow-up results of ruptured aneurysms treated by implantation of a flow diverter device (FDD). METHODS The records of 17 patients (12 females, 5 males, average World Federation of Neurosurgical Societies score = 2.9) who presented with subarachnoid hemorrhage (SAH) due to the rupture of an intracranial aneurysm treated with an FDD were retrospectively reviewed. Of 17 ruptured aneurysms, 8 were blood blister-like aneurysms and the remaining 9 were dissecting aneurysms. The mean delay between SAH and treatment was 4.2 days. Intraprocedural and periprocedural morbidity and mortality were recorded. Clinical and angiographic follow-up evaluations were conducted between 6 and 12 months after the procedure. RESULTS None of the ruptured aneurysms re-bled after endovascular treatment. The overall mortality rate was 12% (2/17), involving 2 patients who died after a few days because of complications of SAH. The overall morbidity rate was 12%: 1 patient experienced intraparenchymal bleeding during the repositioning of external ventricular drainage, and 1 patient with a posterior inferior cerebellar artery aneurysm developed paraplegia due to a spinal cord infarction after 2 weeks. The angiographic follow-up evaluations showed a complete occlusion of the aneurysm in 12 of 15 surviving patients; of the 3 remaining cases, 1 patient showed a remnant of the aneurysm, 1 patient was retreated due to an enlargement of the aneurysm, and 1 patient was lost at the angiographic follow-up. CONCLUSIONS FDDs can be used in patients with ruptured aneurysms, where conventional neurosurgical or endovascular treatments can be challenging.
在这项单中心系列研究中,作者回顾性评估了血流导向装置(FDD)治疗破裂动脉瘤的有效性、安全性和中期随访结果。
回顾性分析了 17 例因颅内动脉瘤破裂导致蛛网膜下腔出血(SAH)并接受 FDD 治疗的患者的病历。17 例破裂动脉瘤中,8 例为血泡样动脉瘤,其余 9 例为夹层动脉瘤。SAH 至治疗的平均时间延迟为 4.2 天。记录术中及围手术期的发病率和死亡率。术后 6-12 个月进行临床和血管造影随访评估。
破裂动脉瘤在血管内治疗后均未再出血。总的死亡率为 12%(2/17),涉及 2 例患者因 SAH 并发症几天后死亡。总的发病率为 12%:1 例患者在外引流重新定位时发生脑实质内出血,1 例后下小脑后动脉动脉瘤患者在 2 周后因脊髓梗死导致截瘫。血管造影随访评估显示,15 例存活患者中有 12 例动脉瘤完全闭塞;其余 3 例中,1 例动脉瘤残留,1 例因动脉瘤增大而再次治疗,1 例在血管造影随访时失访。
FDD 可用于常规神经外科或血管内治疗有困难的破裂动脉瘤患者。