一名艾滋病患者的慢性进行性水痘-带状疱疹病毒脑炎

Chronic progressive varicella-zoster virus encephalitis in an AIDS patient.

作者信息

Gilden D H, Murray R S, Wellish M, Kleinschmidt-DeMasters B K, Vafai A

机构信息

Department of Neurology, Veterans Administration Medical Center, Denver, CO.

出版信息

Neurology. 1988 Jul;38(7):1150-3. doi: 10.1212/wnl.38.7.1150.

DOI:10.1212/wnl.38.7.1150

PMID:2838767

Abstract

A patient with AIDS developed chronic, progressive encephalitis. Pathologic changes indicated that the encephalitis was produced primarily by a human herpesvirus. Hybridization of radiolabeled RNA probes transcribed from cloned DNA fragments of varicella-zoster virus (VZV), herpes simplex virus, cytomegalovirus, and the human immunodeficiency virus to DNA extracted from the patient's brain identified VZV as the causative agent. The results suggest that VZV should be considered in the differential diagnosis of chronic encephalitis of unknown etiology, particularly in immunosuppressed patients.

摘要

一名艾滋病患者发生了慢性进行性脑炎。病理变化表明，该脑炎主要由一种人类疱疹病毒引起。用从水痘 - 带状疱疹病毒（VZV）、单纯疱疹病毒、巨细胞病毒和人类免疫缺陷病毒的克隆DNA片段转录而来的放射性标记RNA探针，与从患者大脑提取的DNA进行杂交，确定VZV为病原体。结果表明，在病因不明的慢性脑炎的鉴别诊断中，应考虑VZV，特别是在免疫抑制患者中。