Lu Y, Lin L-Y, Tan J-G, Deng H-P, Li X-H, Zhang Z, Li Y, Zhou Z, Xu X, Xie X, Mei S-J
Infectious Disease Prevention and Control Department, Shenzhen Center for Disease Control and Prevention, Shenzhen, China.
Eur Rev Med Pharmacol Sci. 2017 Mar;21(6):1290-1295.
Chemokine receptor and its ligand participate in viral immunity and HCV infection, which are important inflammatory mediators. The current study showed the different roles of Th cell secreted chemokines CXCR3, CCR5 and CCR6 in chronic liver inflammation after HCV infection. As one important chemokine receptor, the role of polypeptide property and ligand level in HCV prognosis is still unclear. This study aims to investigate gene polymorphism of chemokine genes and ligand level, and their correlation with patient liver function, to provide evidence for HCV prognosis and chronic transition mechanism.
Whole blood samples were collected. Participants were divided into chronic hepatitis, HCV cirrhosis and self-clearance groups. Chemokine level, gene polymorphism of CXCR3 gene at loci rs2280964 and liver index were measured to analyze their correlation with HCV infection or prognosis.
Gene polymorphism of CXCR3 at loci rs22809064 is one factor-affecting prognosis of HCV patients. CG genotype at these loci is one independent risk factor affecting chronic HCV infection. IP-10, Mig and I-TAC levels were significantly elevated in chronic hepatitis group or HCV cirrhosis group (p< 0.05 compared to self-clearance group).
Gene polymorphism at rs2280964 locus of chemokine receptor CXCR3 is one possible reason explaining differential processes of chronic transition. CXCR3 ligands IP-10, Mig and I-TAC levels were all significantly elevated in chronic hepatitis and HCV cirrhosis patients, possibly functioning as one clinical index for HCV prognosis.
趋化因子受体及其配体参与病毒免疫和丙型肝炎病毒（HCV）感染，是重要的炎症介质。当前研究显示了Th细胞分泌的趋化因子CXCR3、CCR5和CCR6在HCV感染后慢性肝脏炎症中的不同作用。作为一种重要的趋化因子受体，其多肽特性和配体水平在HCV预后中的作用仍不清楚。本研究旨在探讨趋化因子基因的基因多态性和配体水平，以及它们与患者肝功能的相关性，为HCV预后和慢性转变机制提供依据。
采集全血样本。参与者分为慢性肝炎组、HCV肝硬化组和自愈组。检测趋化因子水平、rs2280964位点CXCR3基因的基因多态性以及肝脏指标，以分析它们与HCV感染或预后的相关性。
rs22809064位点CXCR3的基因多态性是影响HCV患者预后的一个因素。这些位点的CG基因型是影响慢性HCV感染的一个独立危险因素。慢性肝炎组或HCV肝硬化组中IP-10、Mig和I-TAC水平显著升高（与自愈组相比，p<0.05）。
趋化因子受体CXCR3的rs2280964位点的基因多态性是解释慢性转变不同过程的一个可能原因。慢性肝炎和HCV肝硬化患者中CXCR3配体IP-10、Mig和I-TAC水平均显著升高，可能作为HCV预后的一个临床指标。
