Qiang Yin, Wang Wei-Feng, Dhodary Basanta, Yang Jun-Li
School of Pharmacy, Lanzhou University, Lanzhou, P. R. China.
CAS Key Laboratory of Chemistry of Northwestern Plant Resources, Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Lanzhou, P. R. China.
Electrophoresis. 2017 Jul;38(13-14):1685-1692. doi: 10.1002/elps.201600569. Epub 2017 May 16.
Macroporous resin has been attracting intensive attention due to its critical role in separation and purification of natural products. Herein, a zeolitic imidazolate framework 8 reinforced macroporous resin D101 was prepared via a room temperature growth method and used for dispersive SPE of 1-naphthol and 2-naphthol. The parameters affecting the adsorption and desorption efficiency such as the sample pH, adsorbent amount, extraction time, desorption solvent, and desorption time were investigated. The as-prepared adsorbent showed selectivity for 1-naphthol and 2-naphthol compared to other phenols. Under the optimum dispersive SPE conditions, the detection of 1-naphthol and 2-naphthol coupled with a CZE method was conducted and the LODs for 1-naphthol and 2-naphthol were 1.37 and 1.43 ng/mL, respectively. Moreover, the results of urine sample analysis showed the spiked recoveries to be in the range of 96.2-106.9%. This study indicated that D101@ZIF-8 (where ZIF is zeolitic imidazolate framework) is a promising selective adsorbent for the analysis of 1-naphthol and 2-naphthol in urine samples.
大孔树脂因其在天然产物分离纯化中的关键作用而备受关注。在此，通过室温生长法制备了一种沸石咪唑酯骨架8增强的大孔树脂D101，并将其用于1-萘酚和2-萘酚的分散固相萃取。研究了样品pH值、吸附剂用量、萃取时间、解吸溶剂和解吸时间等影响吸附和解吸效率的参数。与其他酚类相比，所制备的吸附剂对1-萘酚和2-萘酚具有选择性。在最佳分散固相萃取条件下，采用毛细管区带电泳法对1-萘酚和2-萘酚进行检测，1-萘酚和2-萘酚的检出限分别为1.37和1.43 ng/mL。此外，尿样分析结果表明加标回收率在96.2-106.9%范围内。本研究表明，D101@ZIF-8（其中ZIF为沸石咪唑酯骨架）是一种用于分析尿样中1-萘酚和2-萘酚的有前景的选择性吸附剂。
