Rabah Fatma, El-Naggari Mohamed, Al-Nabhani Dana
Child Health Department, Sultan Qaboos University Hospital, Muscat, Oman.
J Paediatr Child Health. 2017 Jun;53(6):540-542. doi: 10.1111/jpc.13517. Epub 2017 Apr 7.
Amlodipine, a calcium channel blocker became one of the most popular antihypertensive medications used in the paediatric population. This is mainly due to its long half-life making it easy to use as a single daily dose. Amlodipine is associated with common side effects like flushing, headache and dizziness. The incidence of amlodipine-related oedema was noted to be lower in the paediatric population compared to adults. We emphasise the importance of monitoring the development of oedema in patients treated with amlodipine.
Hereby, we report four paediatric cases with amlodipine-related generalised oedema.
Resolution of the oedema with stoppage of amlodipine confirms its culprit as a cause of the oedema. To our knowledge, this is the largest case series of amlodipine-related generalised oedema in the paediatric population.
氨氯地平，一种钙通道阻滞剂，成为儿科人群中最常用的抗高血压药物之一。这主要是由于其半衰期长，便于每日单次给药。氨氯地平会引发如潮红、头痛和头晕等常见副作用。与成人相比，氨氯地平相关水肿在儿科人群中的发生率较低。我们强调在接受氨氯地平治疗的患者中监测水肿发展情况的重要性。
在此，我们报告4例与氨氯地平相关的全身性水肿的儿科病例。
停用氨氯地平后水肿消退，证实其为水肿的病因。据我们所知，这是儿科人群中与氨氯地平相关的全身性水肿的最大病例系列。
