热量限制和运动对肥胖者体内β-内啡肽、促肾上腺皮质激素和皮质醇循环水平的影响。

Effects of caloric restriction and exercise on B-endorphin, ACTH and cortisol circulating levels in obesity.

作者信息

Scavo D, Barletta C, Buzzetti R, Vagiri D

机构信息

I Patologia Medica, University of Rome La Sapienza, Italy.

出版信息

Physiol Behav. 1988;42(1):65-8. doi: 10.1016/0031-9384(88)90261-2.

DOI:10.1016/0031-9384(88)90261-2

PMID:2838854

Abstract

B-Endorphin (B-Ep), ACTH and cortisol circulating levels, before and after a two months therapy with a hypocaloric diet and an increase in physical exercise, were measured by RIA in 17 obese female subjects. After therapy, the body weight excess fell from 56.6 +/- 22.2% to 38.6 +/- 22.1% (p less than 0.01). Plasma levels of B-Ep decreased from 18.3 +/- 12.5 fmol/ml to 6.4 +/- 3.5 fmol/ml (p less than 0.01); those of ACTH from 46.8 +/- 22.8 pg/ml to 31.2 +/- 11.6 pg/ml (p less than 0.01); and those of cortisol from 15.9 +/- 4.6 micrograms% to 10.3 +/- 2.5 micrograms% (p less than 0.01). The reduction of the elevated plasma B-Ep levels found in obese subjects is related principally to the diet therapy. Thus, as shown in experimental animals, excessive feeding results in an increased hypothalamic-pituitary secretion of B-Ep.

摘要

采用放射免疫分析法（RIA）对17名肥胖女性受试者在进行为期两个月的低热量饮食及增加体育锻炼治疗前后的β-内啡肽（β-Ep）、促肾上腺皮质激素（ACTH）和皮质醇的循环水平进行了测定。治疗后，体重超标率从56.6±22.2%降至38.6±22.1%（p<0.01）。血浆β-Ep水平从18.3±12.5fmol/ml降至6.4±3.5fmol/ml（p<0.01）；ACTH水平从46.8±22.8pg/ml降至31.2±11.6pg/ml（p<0.01）；皮质醇水平从15.9±4.6μg%降至10.3±2.5μg%（p<0.01）。肥胖受试者血浆中升高的β-Ep水平降低主要与饮食治疗有关。因此，如实验动物所示，过度进食会导致下丘脑-垂体β-Ep分泌增加。