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主动脉瓣置换术后新发心房颤动:对长期生存的影响。

New-onset postoperative atrial fibrillation after aortic valve replacement: Effect on long-term survival.

机构信息

Department of Cardiology, St Antonius Hospital, Nieuwegein, The Netherlands.

Department of Cardiothoracic Surgery, Academic Medical Center, Amsterdam, The Netherlands.

出版信息

J Thorac Cardiovasc Surg. 2017 Aug;154(2):492-498. doi: 10.1016/j.jtcvs.2017.02.052. Epub 2017 Mar 12.

Abstract

OBJECTIVE

There is a paucity of data on long-term survival of new-onset postoperative atrial fibrillation (POAF) after cardiac surgery. Also, mean follow-up in previous studies is confined to a maximum of one decade. This retrospective, longitudinal cohort study was performed to determine the effect on long-term survival of new-onset POAF after aortic valve replacement (AVR) over a mean follow-up of almost 2 decades.

METHODS

Kaplan-Meier survival analysis was used to determine long-term survival after AVR, performed between January 1, 1990, and January 1, 1994, in 569 consecutive patients without a history of atrial fibrillation, divided into 241 patients (42.4%) with and 328 patients (57.6%) without new-onset POAF. New-onset POAF was considered in multivariable analysis for decreased long-term survival. After AVR, patients with new-onset POAF were treated with the aim to restore sinus rhythm within 24 to 48 hours from onset by medication and when medication failed by direct-current cardioversion before discharge home.

RESULTS

Mean follow-up after AVR was 17.8 ± 1.9 years. Incidence of new-onset POAF was 42.4%. Kaplan-Meier overall cumulative survival rates at 15 years of follow-up were similar in the patients with new-onset POAF versus those without: 41.5% (95% confidence interval [CI], 35.2-47.7) versus 41.3% (95% CI, 36.0-46.7), respectively. New-onset POAF was not an independent risk factor for decreased long-term survival (hazard ratio 0.815; 95% CI, 0.663-1.001; P = .052).

CONCLUSIONS

New-onset POAF after AVR does not affect long-term survival when treatment is aimed to restore sinus rhythm before discharge home.

摘要

目的

心脏手术后新发术后心房颤动(POAF)的长期生存数据很少。此外,以前的研究的平均随访时间最长仅为 10 年。本回顾性纵向队列研究旨在确定主动脉瓣置换术(AVR)后新发 POAF 在近 20 年的平均随访期间对长期生存的影响。

方法

使用 Kaplan-Meier 生存分析来确定 1990 年 1 月 1 日至 1994 年 1 月 1 日之间进行的 AVR 后的长期生存情况,569 例连续患者中无房颤病史,其中 241 例(42.4%)和 328 例(57.6%)新发 POAF。在多变量分析中,新发 POAF 被认为是降低长期生存率的因素。AVR 后,新发 POAF 患者的治疗目标是通过药物在发病后 24 至 48 小时内恢复窦性心律,并在药物治疗失败时在出院前进行直流电复律。

结果

AVR 后的平均随访时间为 17.8±1.9 年。新发 POAF 的发生率为 42.4%。在 15 年的随访中,新发 POAF 患者与无 POAF 患者的总体累积生存率相似:41.5%(95%置信区间[CI],35.2-47.7)与 41.3%(95%CI,36.0-46.7)。新发 POAF 不是降低长期生存率的独立危险因素(风险比 0.815;95%CI,0.663-1.001;P=0.052)。

结论

AVR 后新发 POAF 不会影响出院前恢复窦性心律治疗的长期生存。

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